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Simple numeric abnormalities as primary karyotype changes in ovarian carcinoma
- Source :
- Genes, chromosomescancer. 10(4)
- Publication Year :
- 1994
-
Abstract
- Simple near-diploid karyotypes in ovarian cancer may indicate either primary alterations related to tumor pathogenesis or abnormalities associated with early tumor progression. We have identified a series of 13 epithelial ovarian tumors with very simple karyotypes. Specifically, these karyotypes were near-diploid and displayed numeric abnormalities alone or combined with one or two structural alterations. The present series includes samples from 10 patients with newly diagnosed adenocarcinomas and 3 patients having borderline malignancies. Recurrent numeric abnormalities were identified and included 9/13 cases (69%) with + 12, eight cases (62%) with + 8, five cases (38%) with + 7, three cases (23%) each with + 3 or + 5, and two cases (15%) with -X, Five cases in this series displayed certain numeric abnormalities (+ 12, + 7, and -X) as the sole anomalies, thereby qualifying as primary karyotype changes. Of the 6 cases with structural abnormalities, 4 involved chromosome 19, 2 involved chromosome I, and the remaining abnormalities or translocation partners involved other chromosomes. These findings indicate that some numeric abnormalities are primary karyotype alterations in patients with malignant epithelial ovarian tumors and that chromosome 19 may be preferentially involved in structural rearrangements during early tumor progression. Genes Chromosom Cancer 10:262–266 (1994). © 1994 Wiley-Liss, Inc.
- Subjects :
- Adult
Chromosome Aberrations
Ovarian Neoplasms
Cancer Research
Pathology
medicine.medical_specialty
Chromosome
Cancer
Karyotype
Chromosomal translocation
Biology
Middle Aged
medicine.disease
Tumor progression
Chromosome 19
Ovarian carcinoma
Karyotyping
Immunology
Genetics
medicine
Humans
Female
Ovarian cancer
Aged
Subjects
Details
- ISSN :
- 10452257
- Volume :
- 10
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Genes, chromosomescancer
- Accession number :
- edsair.doi.dedup.....40b4c8c443067f0ab9b2c7704b1ef2cc