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Beneficial Effects of Epigallocatechin-3-O-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases
- Source :
- Molecules, Vol 26, Iss 415, p 415 (2021), Molecules
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Many observational and clinical studies have shown that consumption of diets rich in plant polyphenols have beneficial effects on various diseases such as cancer, obesity, diabetes, cardiovascular diseases, and neurodegenerative diseases (NDDs). Animal and cellular studies have indicated that these polyphenolic compounds contribute to such effects. The representative polyphenols are epigallocatechin-3-O-gallate in tea, chlorogenic acids in coffee, resveratrol in wine, and curcumin in curry. The results of human studies have suggested the beneficial effects of consumption of these foods on NDDs including Alzheimer’s and Parkinson’s diseases, and cellular animal experiments have provided molecular basis to indicate contribution of these representative polyphenols to these effects. This article provides updated information on the effects of these foods and their polyphenols on NDDs with discussions on mechanistic aspects of their actions mainly based on the findings derived from basic experiments.
- Subjects :
- AMPK
NDD
chlorogenic acid
Pharmaceutical Science
Antineoplastic Agents
Review
resveratrol
Resveratrol
Pharmacology
NF-κB
Antioxidants
Catechin
Analytical Chemistry
lcsh:QD241-441
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
lcsh:Organic chemistry
Chlorogenic acid
Drug Discovery
Animals
Humans
Medicine
curcumin
Epigallocatechin-3-O-gallate
Physical and Theoretical Chemistry
Beneficial effects
polyphenols
030304 developmental biology
0303 health sciences
Human studies
business.industry
Organic Chemistry
food and beverages
ROS
Neurodegenerative Diseases
Neuroprotective Agents
chemistry
Chemistry (miscellaneous)
Polyphenol
Curcumin
Molecular Medicine
business
EGCG
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....40b0944dfc32ed7949937838fafb26dd