Back to Search
Start Over
Suitability of UK Biobank Retinal Images for Automatic Analysis of Morphometric Properties of the Vasculature
- Source :
- MacGillivray, T J, Cameron, J R, Zhang, Q, El-Medany, A, Mulholland, C, Sheng, Z, Dhillon, B, Doubal, F N, Foster, P J, Trucco, E, Sudlow, C & UK Biobank Eye and Vision Consortium 2015, ' Suitability of UK Biobank Retinal Images for Automatic Analysis of Morphometric Properties of the Vasculature ' PloS one, vol. 10, no. 5, e0127914 . DOI: 10.1371/journal.pone.0127914, PLoS ONE, PLoS ONE, Vol 10, Iss 5, p e0127914 (2015), MacGillivray, T J, Cameron, J R, Zhang, Q, El-Medany, A, Mulholland, C, Sheng, Z, Dhillon, B, Doubal, F N, Foster, P J, Trucco, E, Sudlow, C 2015, ' Suitability of UK Biobank Retinal Images for Automatic Analysis of Morphometric Properties of the Vasculature ', PLoS ONE, vol. 10, no. 5, pp. e0127914 . https://doi.org/10.1371/journal.pone.0127914
- Publication Year :
- 2015
- Publisher :
- Public Library of Science, 2015.
-
Abstract
- PURPOSE: To assess the suitability of retinal images held in the UK Biobank - the largest retinal data repository in a prospective population-based cohort - for computer assisted vascular morphometry, generating measures that are commonly investigated as candidate biomarkers of systemic disease.METHODS: Non-mydriatic fundus images from both eyes of 2,690 participants - people with a self-reported history of myocardial infarction (n=1,345) and a matched control group (n=1,345) - were analysed using VAMPIRE software. These images were drawn from those of 68,554 UK Biobank participants who underwent retinal imaging at recruitment. Four operators were trained in the use of the software to measure retinal vascular tortuosity and bifurcation geometry.RESULTS: Total operator time was approximately 360 hours (4 minutes per image). 2,252 (84%) of participants had at least one image of sufficient quality for the software to process, i.e. there was sufficient detection of retinal vessels in the image by the software to attempt the measurement of the target parameters. 1,604 (60%) of participants had an image of at least one eye that was adequately analysed by the software, i.e. the measurement protocol was successfully completed. Increasing age was associated with a reduced proportion of images that could be processed (p=0.0004) and analysed (pCONCLUSIONS: A proportion of the retinal images in UK Biobank are of insufficient quality for automated analysis. However, the large size of the UK Biobank means that tens of thousands of images are available and suitable for computational analysis. Parametric information measured from the retinas of participants with suspected cardiovascular disease was significantly different to that measured from a matched control group.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Databases, Factual
Fundus Oculi
Population
lcsh:Medicine
chemistry.chemical_compound
Retinal Diseases
Ophthalmology
Computer software
medicine
Image Processing, Computer-Assisted
Journal Article
Humans
lcsh:Science
education
Aged
education.field_of_study
Multidisciplinary
business.industry
Research Support, Non-U.S. Gov't
lcsh:R
Retinal Vessels
Retinal
Middle Aged
Biobank
chemistry
lcsh:Q
Female
business
Software
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- MacGillivray, T J, Cameron, J R, Zhang, Q, El-Medany, A, Mulholland, C, Sheng, Z, Dhillon, B, Doubal, F N, Foster, P J, Trucco, E, Sudlow, C & UK Biobank Eye and Vision Consortium 2015, ' Suitability of UK Biobank Retinal Images for Automatic Analysis of Morphometric Properties of the Vasculature ' PloS one, vol. 10, no. 5, e0127914 . DOI: 10.1371/journal.pone.0127914, PLoS ONE, PLoS ONE, Vol 10, Iss 5, p e0127914 (2015), MacGillivray, T J, Cameron, J R, Zhang, Q, El-Medany, A, Mulholland, C, Sheng, Z, Dhillon, B, Doubal, F N, Foster, P J, Trucco, E, Sudlow, C 2015, ' Suitability of UK Biobank Retinal Images for Automatic Analysis of Morphometric Properties of the Vasculature ', PLoS ONE, vol. 10, no. 5, pp. e0127914 . https://doi.org/10.1371/journal.pone.0127914
- Accession number :
- edsair.doi.dedup.....40a11eebec24ec531a1cc18016a970c9