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The Role of Metabotropic Glutamate Receptor Genes in Schizophrenia
- Source :
- Scopus-Elsevier, Current Neuropharmacology
- Publication Year :
- 2016
-
Abstract
- Genomic studies revealed two main components in the genetic architecture of schizophrenia, one constituted by common variants determining a distributed polygenic effect and one represented by a large number of heterogeneous rare and highly disruptive mutations. These gene modifications often affect neural transmission and different studies proved an involvement of metabotropic glutamate receptors in schizophrenia phenotype. Through the combination of literature information with genomic data from public repositories, we analyzed the current knowledge on the involvement of genetic variations of the human metabotropic glutamate receptors in schizophrenia and related endophenotypes. Despite the analysis did not reveal a definitive connection, different suggestive associations have been identified and in particular a relevant role has emerged for GRM3 in affecting specific schizophrenia endophenotypes. This supports the hypothesis that these receptors are directly involved in schizophrenia disorder.
- Subjects :
- 0301 basic medicine
Endophenotypes
Schizophrenia (object-oriented programming)
antipsychotic drugs
Biology
Receptors, Metabotropic Glutamate
gene variants
Article
03 medical and health sciences
mental disorders
Genetic variation
Receptors
Metabotropic Glutamate
Humans
Pharmacology (medical)
Receptor
Pharmacology
bioinformatics
General Medicine
Metabotropic glutamate receptors
Phenotype
Genetic architecture
Psychiatry and Mental health
omics data
030104 developmental biology
Neurology
Metabotropic glutamate receptor
Antipsychotic Agents
Schizophrenia
Endophenotype
Neurology (clinical)
Metabotropic glutamate receptor 3
Neuroscience
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier, Current Neuropharmacology
- Accession number :
- edsair.doi.dedup.....409f4ee37460f090ba521063daa86760