Back to Search
Start Over
Relevance of the Materno-Fetal Interface for the Induction of Antigen-Specific Immune Tolerance
- Source :
- Frontiers in Immunology, Frontiers in Immunology, Frontiers, 2020, 11, pp.810. ⟨10.3389/fimmu.2020.00810⟩, Frontiers in Immunology, Vol 11 (2020)
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- International audience; In humans, maternal IgGs are transferred to the fetus from the second trimester of pregnancy onwards. The transplacental delivery of maternal IgG is mediated by its binding to the neonatal Fc receptor (FcRn) after endocytosis by the syncytiotrophoblast. IgGs present in the maternal milk are also transferred to the newborn through the digestive epithelium upon binding to the FcRn. Importantly, the binding of IgGs to the FcRn is also responsible for the recycling of circulating IgGs that confers them with a long half-life. Maternally delivered IgG provides passive immunity to the newborn, for instance by conferring protective anti-flu or anti-pertussis toxin IgGs. It may, however, lead to the development of autoimmune manifestations when pathological autoantibodies from the mother cross the placenta and reach the circulation of the fetus. In recent years, strategies that exploit the transplacental delivery of antigen/IgG complexes or of Fc-fused proteins have been validated in mouse models of human diseases to impose antigen-specific tolerance, particularly in the case of Fc-fused factor VIII (FVIII) domains in hemophilia A mice or pre-pro-insulin (PPI) in the case of preclinical models of type 1 diabetes (T1D). The present review summarizes the mechanisms underlying the FcRn-mediated transcytosis of IgGs, the physiopathological relevance of this phenomenon, and the repercussion for drug delivery and shaping of the immune system during its ontogeny.
- Subjects :
- 0301 basic medicine
Placenta
medicine.medical_treatment
Review
Receptors, Fc
Passive immunity
Immune tolerance
Mice
0302 clinical medicine
Pregnancy
Immunology and Allergy
Medicine
Maternal-Fetal Exchange
immune tolerance induction
immune system ontogeny
3. Good health
Protein Transport
medicine.anatomical_structure
Transcytosis
[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology
[SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunology
Female
hemophilia A
lcsh:Immunologic diseases. Allergy
maternal IgG
Immunology
03 medical and health sciences
neonatal Fc receptor (FcRn)
Fetus
Neonatal Fc receptor
Immune system
Antigen
Immune Tolerance
Animals
Humans
Antigens
Autoantibodies
therapy
business.industry
Histocompatibility Antigens Class I
Transplacental
030104 developmental biology
Immune System
Immunoglobulin G
lcsh:RC581-607
business
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology, Frontiers in Immunology, Frontiers, 2020, 11, pp.810. ⟨10.3389/fimmu.2020.00810⟩, Frontiers in Immunology, Vol 11 (2020)
- Accession number :
- edsair.doi.dedup.....4091ff0f7673f92c2e94ea8676c88e72