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Efficacy and safety of tianeptine in the treatment of depressive disorders in comparison with fluoxetine*
- Source :
- Human psychopharmacology. 16(S1)
- Publication Year :
- 2002
-
Abstract
- Depression is treated by a great variety of antidepressant treatments. SSRIs (such as fluoxetine) are well known: it is, however, sure that further progress is needed and the search for antidepressants with other mechanisms of action (such as tianeptine) or different efficacy is still of interest. A multinational study compared tianeptine with fluoxetine in 387 patients with Depressive Episode, or Recurrent Depressive Disorder, or Bipolar Affective Disorder (ICD-10), in a double-blind parallel group design. They were treated for six weeks. At inclusion, no significant difference between groups was shown. Final MADRS scores were 15.7 and 15.8 with tianeptine and fluoxetine, respectively (ITT population) (p = 0.944). MADRS responders were 58% and 56% with tianeptine and fluoxetine, respectively (p = 0.710). No statistical difference was observed for the other efficacy parameters. Thirty-six withdrawals occurred in each group, without any difference for the reasons of discontinuation. There was no major difference between groups for the other safety parameters. In this study, both tianeptine and fluoxetine exhibited a good efficacy and safety. Copyright © 1999 Elsevier Science B. V. All rights reserved.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Thiazepines
Population
Statistical difference
Antidepressive Agents, Tricyclic
law.invention
Double-Blind Method
Randomized controlled trial
law
Fluoxetine
Internal medicine
medicine
Humans
Pharmacology (medical)
Tianeptine
Psychiatry
education
Depression (differential diagnoses)
Aged
Depressive Disorder
education.field_of_study
Significant difference
Middle Aged
Discontinuation
Clinical trial
Psychiatry and Mental health
Clinical Psychology
Treatment Outcome
Neurology
Antidepressive Agents, Second-Generation
Antidepressant
Female
Neurology (clinical)
Psychology
Reuptake inhibitor
medicine.drug
Subjects
Details
- ISSN :
- 10991077
- Volume :
- 16
- Issue :
- S1
- Database :
- OpenAIRE
- Journal :
- Human psychopharmacology
- Accession number :
- edsair.doi.dedup.....407c4e8e0b9e7fbf302336ffac96fec9