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Fluoxetine: a review of receptor and functional effects and their clinical implications
- Source :
- Psychopharmacology. 107(1)
- Publication Year :
- 1992
-
Abstract
- Downregulation of serotonin 5-HT1 receptors is the most frequently reported central nervous system neural effect of subchronic exposure to fluoxetine in rodents. However, downregulation of these receptors has not been universally demonstrated. Effects of subchronic exposure on 5-HT2 receptors are mixed. Fluoxetine exposure appears to have no effect on cholinergic muscarinic receptors. Effects on beta-adrenergic receptors are controversial, as only one laboratory has reported down-regulation. The majority of studies have failed to show an effect on beta-adrenergic-receptor-stimulated cAMP generation. Electrophysiologic studies support the concept that fluoxetine facilitates net serotonergic transmission through downregulation of presynaptic inhibitory autoreceptors. Data suggest that its subchronic specificity and selectivity distinguish fluoxetine from members of other classes of available antidepressants, making it a distinct therapeutic option.
- Subjects :
- medicine.medical_specialty
Down-Regulation
Pharmacology
Serotonergic
Synaptic Transmission
Downregulation and upregulation
Internal medicine
Fluoxetine
Muscarinic acetylcholine receptor
medicine
Animals
Neurotransmitter Uptake Inhibitors
Receptor
Behavior, Animal
Antidepressive Agents
Electrophysiology
Kinetics
Endocrinology
Mechanism of action
Receptors, Serotonin
Antidepressant
Serotonin
medicine.symptom
Psychology
medicine.drug
Subjects
Details
- ISSN :
- 00333158
- Volume :
- 107
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Psychopharmacology
- Accession number :
- edsair.doi.dedup.....405cd495fd1966b0ac6e5e5b0684d3c8