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Co-administration of Luteolin mitigated toxicity in rats' lungs associated with doxorubicin treatment
- Source :
- Toxicology and applied pharmacology. 411
- Publication Year :
- 2020
-
Abstract
- Doxorubicin (DOX), is a drug against lung malignancies with undesirable side effect including oxidative, inflammatory and apoptotic effects. Luteolin (LUT), present in fruits and vegetables is pharmacologically active against oxido-inflammatory and apoptotic responses. The present study examined the effect of LUT on DOX-induced lungs and blood dysfunction in Wistars rat (sex: male; 10 weeks old, 160 ± 5 g). Randomly grouped (n = 10) rats were treated as follows: control, LUT alone (100 mg/kg; per os), DOX (2 mg/kg; i. p), and co-treated rats with LUT (50 or 100 mg/kg) and DOX for two consecutive weeks. DOX alone adversely altered the final body and relative organ weights, red and white blood cell and platelet counts. DOX significantly (p > 0.05) reduced lungs antioxidant capacity, and anti-inflammatory cytokines; increased biomarkers of oxidative stress, caspase-3 activity, and pro-inflammatory cytokine. Morphological damages accompanied these biochemical alterations in the lung of experimental rats. Co-treatment with LUT, dose-dependently reversed DOX-mediated changes in rats' survival, toxic responses, and diminished oxidative stress in rat's lungs. Furthermore, co-treatment with LUT resulted in the reduction of pro-inflammatory cytokines and apoptotic biomarkers, increased red and white blood cell, platelet counts and abated pathological injuries in rat lungs treated with DOX alone. In essence, our findings indicate that LUT dose-dependently mitigated DOX-induced toxicities in the lungs and haematopoietic systems. Supplementation of patients on DOX-chemotherapy with phytochemicals exhibiting antioxidant activities, specifically LUT, could circumvent the onset of unintended toxic responses in the lungs and haematopoietic system exposed to DOX.
- Subjects :
- 0301 basic medicine
Male
Side effect
Pulmonary toxicity
medicine.medical_treatment
Anti-Inflammatory Agents
Apoptosis
Pharmacology
Toxicology
medicine.disease_cause
Antioxidants
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
White blood cell
polycyclic compounds
medicine
Animals
Rats, Wistar
Luteolin
Lung
business.industry
Lung Injury
carbohydrates (lipids)
Disease Models, Animal
Oxidative Stress
030104 developmental biology
Cytokine
medicine.anatomical_structure
chemistry
Doxorubicin
030220 oncology & carcinogenesis
Toxicity
Cytokines
Inflammation Mediators
business
Apoptosis Regulatory Proteins
Oxidative stress
Subjects
Details
- ISSN :
- 10960333
- Volume :
- 411
- Database :
- OpenAIRE
- Journal :
- Toxicology and applied pharmacology
- Accession number :
- edsair.doi.dedup.....405592798cdb579af251ebabf1feb9a9