Back to Search
Start Over
Sorting out the complexity of SR protein functions
- Source :
- RNA. 6:1197-1211
- Publication Year :
- 2000
- Publisher :
- Cold Spring Harbor Laboratory, 2000.
-
Abstract
- been clear whether all of these activities occur during the removal of each intron+ Recent studies now suggest that all of the proposed SR protein functions are carried out during each round of splicing, and at least some of these functions are performed by independent SR protein molecules+ This review discusses recent advances in understanding the diverse functions of SR proteins in metazoan pre-mRNA splicing and presents a model that takes these new findings into account+ Although the reader should keep in mind that the activity of SR proteins in vivo can be influenced by modulating their subcellular localization, this review focuses on biochemical experiments that specifically address the mechanisms by which SR proteins directly function in the splicing reaction+ (The reader may also refer to related reviews recently published elsewhere (Tacke & Manley, 1999; Blencowe, 2000)+)
- Subjects :
- Genetics
Serine-Arginine Splicing Factors
Protein Conformation
RNA Splicing
Intron
Exonic splicing enhancer
Nuclear Proteins
RNA-Binding Proteins
RNA-binding protein
Exons
Computational biology
SRPK1
Biology
Phosphoproteins
Ribonucleoproteins, Small Nuclear
Splicing factor
SR protein
RNA splicing
RNA Precursors
Spliceosomes
Humans
Molecular Biology
Exonic splicing silencer
Research Article
Subjects
Details
- ISSN :
- 13558382
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- RNA
- Accession number :
- edsair.doi.dedup.....40546f04d59d9d6eb1531dbf67ba035c