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The Effect of Zoledronic Acid on the Clinical Resolution of Charcot Neuroarthropathy
- Source :
- Diabetes Care
- Publication Year :
- 2011
- Publisher :
- American Diabetes Association, 2011.
-
Abstract
- OBJECTIVE To investigate the clinical efficacy of zoledronic acid in patients with diabetes and acute Charcot neuroarthropathy. RESEARCH DESIGN AND METHODS Thirty-nine consecutive patients were randomly assigned to placebo or three intravenous infusions of 4 mg zoledronic acid. The primary outcome was clinical resolution of acute Charcot neuroarthropathy determined by total immobilization time (casting plus orthosis). RESULTS At baseline, there was no significant difference between the randomly assigned groups with respect to Charcot disease activity or other baseline values. In the zoledronic acid group, the median time for total immobilization was 27 weeks (range 10–62), and in the placebo group it was 20 weeks (20–52) (P = 0.02). CONCLUSIONS Zoledronic acid had no beneficial effect on the clinical resolution of acute Charcot neuroarthropathy in terms of total immobilization time. It is possible that it may prolong the time to clinical resolution of Charcot neuroarthropathy.
- Subjects :
- Adult
Male
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Randomization
Endocrinology, Diabetes and Metabolism
Urology
Pilot Projects
Placebo
Zoledronic Acid
law.invention
Foot Diseases
Diabetic Neuropathies
Double-Blind Method
Randomized controlled trial
law
Diabetes mellitus
Arthropathy
Internal Medicine
medicine
Humans
Original Research
Advanced and Specialized Nursing
Diphosphonates
business.industry
Clinical Care/Education/Nutrition/Psychosocial Research
Imidazoles
Middle Aged
medicine.disease
Charcot neuroarthropathy
Surgery
Clinical trial
Zoledronic acid
Female
Arthropathy, Neurogenic
business
medicine.drug
Subjects
Details
- ISSN :
- 19355548 and 01495992
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Diabetes Care
- Accession number :
- edsair.doi.dedup.....4049573c926250fcaa55870f9ee4c73d