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PANCREATIC TOXICITY AS AN ADVERSE EFFECT INDUCED BY MEGLUMINE ANTIMONIATE THERAPY IN A CLINICAL TRIAL FOR CUTANEOUS LEISHMANIASIS
- Source :
- Revista do Instituto de Medicina Tropical de São Paulo, Volume: 58, Article number: 68, Published: 22 SEP 2016, Revista do Instituto de Medicina Tropical de São Paulo, Revista do Instituto de Medicina Tropical de São Paulo, Vol 58, Iss 0
- Publication Year :
- 2016
- Publisher :
- Instituto de Medicina Tropical, 2016.
-
Abstract
- SUMMARY American tegumentary leishmaniasis is an infectious disease caused by a protozoan of the genus Leishmania. Pentavalent antimonials are the first choice drugs for cutaneous leishmaniasis (CL), although doses are controversial. In a clinical trial for CL we investigated the occurrence of pancreatic toxicity with different schedules of treatment with meglumine antimoniate (MA). Seventy-two patients were allocated in two different therapeutic groups: 20 or 5 mg of pentavalent antimony (Sb5+)/kg/day for 20 or 30 days, respectively. Looking for adverse effects, patients were asked about abdominal pain, nausea, vomiting or anorexia in each medical visit. We performed physical examinations and collected blood to evaluate serum amylase and lipase in the pre-treatment period, and every 10 days during treatment and one month post-treatment. Hyperlipasemia occurred in 54.8% and hyperamylasemia in 19.4% patients. Patients treated with MA 20 mg Sb5+ presented a higher risk of hyperlipasemia (p = 0.023). Besides, higher MA doses were associated with a 2.05 higher risk ratio (p = 0.003) of developing more serious (moderate to severe) hyperlipasemia. The attributable fraction was 51% in this group. Thirty-six patients presented abdominal pain, nausea, vomiting or anorexia but only 47.2% of those had hyperlipasemia and/ or hyperamylasemia. These findings suggest the importance of the search for less toxic therapeutic regimens for the treatment of CL.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Abdominal pain
lcsh:Arctic medicine. Tropical medicine
Nausea
lcsh:RC955-962
Meglumine antimoniate
030106 microbiology
Gastroenterology
03 medical and health sciences
Cutaneous leishmaniasis
Internal medicine
medicine
Adverse effect
business.industry
General Medicine
medicine.disease
Surgery
Clinical trial
Infectious Diseases
Pancreatitis
Vomiting
Hyperamylasemia
Original Article
Therapy
medicine.symptom
business
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Revista do Instituto de Medicina Tropical de São Paulo, Volume: 58, Article number: 68, Published: 22 SEP 2016, Revista do Instituto de Medicina Tropical de São Paulo, Revista do Instituto de Medicina Tropical de São Paulo, Vol 58, Iss 0
- Accession number :
- edsair.doi.dedup.....402c6e0d2ab479edd745ab04e6178818