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Prevalence of anemia in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB)
- Source :
- PLoS ONE, Vol 15, Iss 7, p e0236132 (2020), PLoS ONE
- Publication Year :
- 2020
- Publisher :
- Public Library of Science (PLoS), 2020.
-
Abstract
- BackgroundThe Japan Chronic Kidney Disease Database (J-CKD-DB) is a nationwide clinical database of patients with chronic kidney disease (CKD) based on electronic health records. The objective of this study was to assess the prevalence of anemia and the utilization rate of erythropoiesis-stimulating agents (ESAs) in Japanese patients with CKD.MethodsIn total, 31,082 adult outpatients with estimated glomerular filtration rates of 5-60 ml/min/1.73 m2 in seven university hospitals were included this analysis. The proportions of patients with CKD stages G3b, G4, and G5 were 23.5%, 7.6%, and 3.1%, respectively.ResultsThe mean (standard deviation) hemoglobin level of male patients was 13.6 (1.9) g/dl, which was significantly higher than the mean hemoglobin level of female patients (12.4 (1.6) g/dl). The mean (standard deviation) hemoglobin levels were 11.4 (2.1) g/dl in patients with CKD stage G4 and 11.2 (1.8) g/dl in patients with CKD stage G5. The prevalences of anemia were 40.1% in patients with CKD stage G4 and 60.3% in patients with CKD stage G5. Logistic regression analysis showed that diagnoses of CKD stage G3b (adjusted odds ratio [95% confidence interval]: 2.32 [2.09-2.58]), G4 (5.50 [4.80-6.31]), and G5 (9.75 [8.13-11.7]) were associated with increased prevalence of anemia. The utilization rates of ESAs were 7.9% in patients with CKD stage G4 and 22.4% in patients with CKD stage G5.ConclusionsWe determined the prevalence of anemia and utilization rate of ESAs in Japanese patients with CKD using data from a nationwide cohort study.
- Subjects :
- Male
Databases, Factual
Cross-sectional study
030232 urology & nephrology
030204 cardiovascular system & hematology
Pathology and Laboratory Medicine
urologic and male genital diseases
computer.software_genre
Biochemistry
Cohort Studies
Geographical Locations
Hemoglobins
0302 clinical medicine
Japan
Chronic Kidney Disease
Outpatients
Prevalence
Medicine and Health Sciences
Multidisciplinary
Proteinuria
Database
Anemia
Hematology
Middle Aged
female genital diseases and pregnancy complications
Nephrology
Medicine
Female
medicine.symptom
Glomerular Filtration Rate
Research Article
Cohort study
Asia
Patients
Science
Renal function
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Medical Dialysis
medicine
Humans
Hemoglobin
Renal Insufficiency, Chronic
Treatment Guidelines
Health Care Policy
business.industry
Biology and Life Sciences
Proteins
Odds ratio
medicine.disease
Confidence interval
Health Care
Cross-Sectional Studies
People and Places
business
computer
Kidney disease
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....401d42b27903ba1003b8ffb17271b020