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Effects of indomethacin on kidney function in Type 1 (insulin-dependent) diabetic patients with nephropathy
- Source :
- Diabetologia. 30:78-81
- Publication Year :
- 1987
- Publisher :
- Springer Science and Business Media LLC, 1987.
-
Abstract
- We investigated whether the glomerular synthesis of prostaglandins modulates the glomerular filtration rate and albuminuria in diabetic nephropathy. The urinary excretion of immunoreactive prostaglandin E2 (253 pg/min) was significantly elevated in eight Type 1 (insulin-dependent) diabetic women with nephropathy as compared with nine normoalbuminuric Type 1 diabetic women (95 pg/min) and 11 non-diabetic women (132 pg/min), respectively (p less than 0.01). Glomerular filtration rate (single bolus 51Cr-EDTA technique) and albuminuria (radioimmunoassay) were measured twice within two weeks in the eight Type 1 diabetic women with nephropathy. All eight patients were on a diabetic diet without sodium restriction. The study was performed as a randomized double-blind trial, with the patients receiving either indomethacin (150 mg/day) or placebo for three days prior to the kidney function studies. Indomethacin treatment induced a significant reduction in urinary prostaglandin E2 excretion (73%, p less than 0.01), glomerular filtration rate diminished from 120 +/- 18 to 106 +/- 17 ml/min/1.73 m2 (p less than 0.05), albuminuria declined from 148 to 69 micrograms/min (median and range) (p less than 0.05) and fractional clearance of albumin diminished 42% (p less than 0.05). Blood glucose concentrations were comparable during the placebo and indomethacin treatment, 13.4 +/- 4 versus 14.2 +/- 3 mmol/l, respectively. Our results suggest that glomerular filtration rate in early diabetic nephropathy is dependent on the enhanced glomerular synthesis of vasodilating prostaglandins.
- Subjects :
- Adult
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Urinary system
Indomethacin
Kidney Glomerulus
Renal function
Dinoprostone
Nephropathy
Diabetic nephropathy
Excretion
Random Allocation
Double-Blind Method
Internal medicine
Internal Medicine
medicine
Albuminuria
Humans
Diabetic Nephropathies
Prostaglandin E2
Type 1 diabetes
business.industry
Prostaglandins E
Middle Aged
medicine.disease
Diabetes Mellitus, Type 1
Endocrinology
Female
medicine.symptom
business
Glomerular Filtration Rate
medicine.drug
Subjects
Details
- ISSN :
- 14320428 and 0012186X
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Diabetologia
- Accession number :
- edsair.doi.dedup.....4018dcbd11d60b300351f2a0ad964ed8