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Metabolic reprogramming of pyruvate dehydrogenase is essential for the proliferation of glioma cells expressing mutant IDH1
- Source :
- Molecular & cellular oncology, vol 3, iss 2
- Publication Year :
- 2016
- Publisher :
- eScholarship, University of California, 2016.
-
Abstract
- Mutations in isocitrate dehydrogenase 1 (IDH1) characterize most adult low-grade gliomas. Mutant IDH1 catalyzes production of the oncometabolite 2-hydroxyglutarate (2-HG). We recently discovered that the IDH1 mutation also reprograms pyruvate metabolism in a 2-HG-dependent manner, and that reprogramming of pyruvate metabolism is essential for cell proliferation in glioma cells with mutant IDH1.
- Subjects :
- 0301 basic medicine
Cancer Research
IDH1
Pyruvate dehydrogenase kinase
Mutant
Biology
03 medical and health sciences
Rare Diseases
pyruvate dehydrogenase
Glioma
medicine
metabolic reprogramming
Author's View
Cancer
Cell growth
Neurosciences
2-HG
Pyruvate dehydrogenase complex
medicine.disease
Cell biology
Brain Disorders
gliomas
Brain Cancer
030104 developmental biology
Isocitrate dehydrogenase
Biochemistry
Molecular Medicine
Reprogramming
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Molecular & cellular oncology, vol 3, iss 2
- Accession number :
- edsair.doi.dedup.....4017ff1b377bfe45953222dd8e1b1bae