Conditions of wound healing and cutaneous growth affect metabolic performance of skin following plastic surgery

Authors :: Dominique Casanova
Guy Magalon
Patrick J. Cozzone
Lucile Andrac-Meyer
Norbert W. Lutz
Sylviane Confort-Gouny
Centre de résonance magnétique biologique et médicale (CRMBM)
Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
Ben Dahan, David
Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)
Source :: Wound Repair and Regeneration, Wound Repair and Regeneration, Wiley, 2007, 15 (4), pp.491-496, Wound Repair and Regeneration, 2007, 15 (4), pp.491-496
Publication Year :: 2007
Publisher :: Wiley, 2007.
Abstract: The mechanical and structural properties of skin subjected to expansion have been widely investigated in the context of plastic surgery. To determine the actual metabolic state of skin following skin expander placement, we determined the basic biochemical parameters for various conditions of postsurgical wound healing and cutaneous growth. Studying, for the first time, comprehensive metabolic profiles ("metabolomics") of the skin in a minipig model, we found that the lactate/alanine ratios were significantly increased (p

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