Serum exosomal miR-4772-3p is a predictor of tumor recurrence in stage II and III colon cancer

// Chang Liu 1, 4 , Cathy Eng 1 , Jianjun Shen 3 , Yue Lu 3 , Yoko Takata 3 , Amir Mehdizadeh 1 , George J. Chang 2 , Miguel A. Rodriguez-Bigas 2 , Yanan Li 1 , Ping Chang 1 , Yixiang Mao 1 , Manal M. Hassan 1 , Fangyu Wang 4 , Donghui Li 1 1 Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 2 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 3 Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, Texas, USA 4 Department of Gastroenterology and Hepatology, Jinling Hospital, Southern Medical University, Nanjing, China Correspondence to: Donghui Li, email: dli@mdanderson.org Fangyu Wang, email: wangfy65@nju.edu.cn Keywords: exosome, microRNA, colon cancer, qRT-PCR, Illumina RNA sequencing Received: April 22, 2016 Accepted: October 11, 2016 Published: October 24, 2016 ABSTRACT Purpose: The study was aimed to evaluate the prognostic or predictive value of serum exosomal microRNAs (miRNAs) for tumor recurrence and response to adjuvant therapy in stage II and stage III colon cancer. Results: 145 differentially expressed mature miRNAs were identified ( P