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Mathematical modelling of bone remodelling cycles including the NFκB signalling pathway
- Source :
- Computers in Biology and Medicine. 107:257-264
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- RANKL can promote the differentiation of osteoclast precursors into mature osteoclasts by binding to RANK expressed on the surfaces of osteoclast progenitor cells during bone remodelling. The NF-κB signalling pathway is downstream of RANKL and transmits the RANKL signal to nuclear promoter-bound protein complexes from cell surface receptors, which then regulates target gene expression to facilitate osteoclastogenesis. However, this important role of the NF-κB signalling pathway is usually ignored in published mathematical models of bone remodelling. This paper describes the construction of a mathematical model of bone remodelling in a normal bone microenvironment with inclusion of the NF-κB signalling pathway. The model consisted of a set of ordinary differential equations and reconstructed variations in the bone cells, resultant bone volume, and biochemical factors involved in the NF-κB signalling pathway over time. The model was used to investigate how the NF-κB pathway is activated in osteoclast precursors to promote osteoclastogenesis during bone remodelling. Model simulations agreed well with published experimental data. It is hoped that this model can improve our understanding of bone remodelling. It has the obvious potential to examine the influence of NF-κB dysregulation on bone remodelling, and even propose potential therapeutic strategies to combat related bone diseases in future research.
- Subjects :
- 0301 basic medicine
Osteoclasts
Health Informatics
Models, Biological
Bone remodeling
03 medical and health sciences
0302 clinical medicine
Osteogenesis
Cell surface receptor
Osteoclast
Bone cell
medicine
Animals
Computer Simulation
Progenitor cell
Osteoblasts
biology
Chemistry
RANK Ligand
NF-kappa B
Hedgehog signaling pathway
Computer Science Applications
Cell biology
030104 developmental biology
medicine.anatomical_structure
RANKL
biology.protein
Bone Remodeling
Bone volume
030217 neurology & neurosurgery
Signal Transduction
Subjects
Details
- ISSN :
- 00104825
- Volume :
- 107
- Database :
- OpenAIRE
- Journal :
- Computers in Biology and Medicine
- Accession number :
- edsair.doi.dedup.....3ff165b1c3c18ad2f5fc93bdd540399d