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Association between -174G/C and -572G/C interleukin 6 gene polymorphisms and severe radiographic damage to the hands of Mexican patients with rheumatoid arthritis: a preliminary report
- Source :
- Genetics and molecular research : GMR. 15(4)
- Publication Year :
- 2016
-
Abstract
- Several interleukin 6 gene (IL6) polymorphisms are implicated in susceptibility to rheumatoid arthritis (RA). It has not yet been established with certainty if these polymorphisms are associated with the severe radiographic damage observed in some RA patients, particularly those with the development of joint bone ankylosis (JBA). The objective of the present study was to evaluate the association between severe radiographic damage in hands and the -174G/C and -572G/C IL6 polymorphisms in Mexican Mestizo people with RA. Mestizo adults with RA and long disease duration (>5 years) were classified into two groups according to the radiographic damage in their hands: a) severe radiographic damage (JBA and/or joint bone subluxations) and b) mild or moderate radiographic damage. We compared the differences in genotype and allele frequencies of -174G/C and -572G/C IL6 polymorphisms (genotyped using polymerase chain reaction-restriction fragment length polymorphism) between these two groups. Our findings indicated that the -174G/C polymorphism of IL6 is associated with severe joint radiographic damage [maximum likelihood odds ratios (MLE_OR): 8.03; 95%CI 1.22-187.06; P = 0.03], whereas the -572G/C polymorphism of IL6 exhibited no such association (MLE_OR: 1.5; 95%CI 0.52-4.5; P = 0.44). Higher anti-cyclic citrullinated peptide antibody levels were associated with more severe joint radiographic damage (P = 0.04). We conclude that there is a relevant association between the -174G/C IL6 polymorphism and severe radiographic damage. Future studies in other populations are required to confirm our findings.
- Subjects :
- Adult
Male
medicine.medical_specialty
Interleukin 6 gene
Radiography
030209 endocrinology & metabolism
Gastroenterology
Polymorphism, Single Nucleotide
Arthritis, Rheumatoid
03 medical and health sciences
0302 clinical medicine
Internal medicine
Genotype
Genetics
medicine
Ankylosis
Humans
Genetic Predisposition to Disease
Interleukin 6
Molecular Biology
Allele frequency
Mexico
030203 arthritis & rheumatology
biology
business.industry
Interleukin-6
Hand Injuries
General Medicine
Odds ratio
Middle Aged
medicine.disease
Hand
Rheumatoid arthritis
biology.protein
Female
business
Subjects
Details
- ISSN :
- 16765680
- Volume :
- 15
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Genetics and molecular research : GMR
- Accession number :
- edsair.doi.dedup.....3fe25ea4ccd87f8e66a550c84cb5df06