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Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses
- Source :
- Biological Psychiatry. 65:263-267
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- Background Adverse early life events are associated with a maladaptive stress response system and might increase the vulnerability to disease in later life. Several disorders have been associated with early life stress, ranging from depression to irritable bowel syndrome. This makes the identification of the neurobiological substrates that are affected by adverse experiences in early life invaluable. Methods The purpose of this study was to assess the effect of early life stress on the brain-gut axis. Male rat pups were stressed by separating them from their mothers for 3 hours daily between postnatal days 2–12. The control group was left undisturbed with their mothers. Behavior, immune response, stress sensitivity, visceral sensation, and fecal microbiota were analyzed. Results The early life stress increased the number of fecal boli in response to a novel stress. Plasma corticosterone was increased in the maternally separated animals. An increase in the systemic immune response was noted in the stressed animals after an in vitro lipopolysaccharide challenge. Increased visceral sensation was seen in the stressed group. There was an alteration of the fecal microbiota when compared with the control group. Conclusions These results show that this form of early life stress results in an altered brain-gut axis and is therefore an important model for investigating potential mechanistic insights into stress-related disorders including depression and IBS.
- Subjects :
- DNA, Bacterial
Lipopolysaccharides
medicine.medical_specialty
Colon
Central nervous system
Physiology
Disease
Nucleic Acid Denaturation
Irritable Bowel Syndrome
Rats, Sprague-Dawley
Feces
chemistry.chemical_compound
Immune system
Immunity
Corticosterone
Physical Stimulation
RNA, Ribosomal, 16S
Internal medicine
medicine
Animals
Biological Psychiatry
Depression (differential diagnoses)
Irritable bowel syndrome
Reverse Transcriptase Polymerase Chain Reaction
Mental Disorders
Rectum
Flow Cytometry
medicine.disease
Hormones
Rats
Endocrinology
medicine.anatomical_structure
Animals, Newborn
chemistry
Cytokines
Electrophoresis, Polyacrylamide Gel
Psychology
Stress, Psychological
Hormone
Subjects
Details
- ISSN :
- 00063223
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- Biological Psychiatry
- Accession number :
- edsair.doi.dedup.....3fca1557e2ea6bc48817698de54465fa