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Growth characteristics and metastatic potential of seven intestinal carcinoma lines serially passaged in syngeneic rats
- Source :
- Virchows Archiv A Pathological Anatomy and Histopathology. 418:193-199
- Publication Year :
- 1991
- Publisher :
- Springer Science and Business Media LLC, 1991.
-
Abstract
- Transplantable tumour lines were obtained from one duodenal carcinoma induced by N-methyl-N'-nitro-N-nitrosoguanidine in the Lewis rat and from six colonic carcinomas induced by 1,2 dimethylhydrazine in BDIX or Fisher rats. The tumours were serially transplanted by the subcutaneous route into homologous syngeneic rats. The seven tumours differ from one another in their histological structure, five of them being well or moderately differentiated adenocarcinomas, and in their capacity to produce neutral or acidic mucins. The seven tumours also differ in their growth rate. The seven lines produced metastases; the metastatic potential and the location of the metastases differed from one line to another. The seven lines kept their original differentiation characteristics through multiple passages, representing several years of transplantation into syngeneic hosts. These tumours represent a useful and diversified model of metastatic intestinal carcinoma, available for basic research and therapeutic trials.
- Subjects :
- Pathology
medicine.medical_specialty
Epithelioma
Carcinoma
Mucin
Rats, Inbred Strains
Cell Biology
General Medicine
Biology
medicine.disease
Rats
Pathology and Forensic Medicine
Metastasis
Transplantation
Transplantation, Isogeneic
Intestinal Neoplasms
Tumor Cells, Cultured
Dimethylhydrazine
medicine
Homologous chromosome
Animals
Duodenal Carcinoma
Molecular Biology
Neoplasm Transplantation
Subjects
Details
- ISSN :
- 14322307 and 01747398
- Volume :
- 418
- Database :
- OpenAIRE
- Journal :
- Virchows Archiv A Pathological Anatomy and Histopathology
- Accession number :
- edsair.doi.dedup.....3fc5a8174b36a60ca678274993a57e3b