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The anticancer drug imatinib induces autophagy in Schistosoma mansoni
- Source :
- International Journal for Parasitology. 52:211-215
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Schistosomiasis, caused by schistosome parasites, is a neglected tropical disease affecting humans and animals. There is no vaccine available yet, and fear of upcoming resistance against the only widely used drug, praziquantel, is omnipresent. Previously, we showed that imatinib (Gleevec), an anticancer drug, affected schistosome physiology and caused the death of adult Schistosoma mansoni in vitro. Here, we present the first known evidence that one effect of imatinib is the induction of autophagy in S. mansoni. Furthermore, worms co-treated with imatinib and bafilomycin A1, a late-phase autophagy inhibitor, reversed imatinib-induced autophagy and its antischistosomal effects as revealed by phenotypic and molecular analyses.
- Subjects :
- Drug
media_common.quotation_subject
Antineoplastic Agents
Schistosomiasis
Biology
Pharmacology
Praziquantel
hemic and lymphatic diseases
parasitic diseases
Autophagy
medicine
Animals
media_common
Tropical disease
Imatinib
Schistosoma mansoni
medicine.disease
biology.organism_classification
Schistosomiasis mansoni
In vitro
Infectious Diseases
Imatinib Mesylate
Parasitology
medicine.drug
Subjects
Details
- ISSN :
- 00207519
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- International Journal for Parasitology
- Accession number :
- edsair.doi.dedup.....3fb8a93ac022803503b6f13aff529bbc