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Offspring Metabolomic Response to Maternal Protein Restriction in a Rat Model of Intrauterine Growth Restriction (IUGR)
- Source :
- Journal of Proteome Research, Journal of Proteome Research, American Chemical Society, 2011, 10 (7), pp.3292-3302. ⟨10.1021/pr2003193⟩
- Publication Year :
- 2011
- Publisher :
- HAL CCSD, 2011.
-
Abstract
- International audience; Intrauterine growth restriction (IUGR), along with postnatal growth trajectory, is closely linked with metabolic diseases and obesity at adulthood. The present study reports the time-dependent metabolomic response of male offspring of rat dams exposed to maternal adequate protein diet during pregnancy and lactation (CC) or protein deprivation during pregnancy only (IUGR with rapid catch-up growth, RC) or through pregnancy and lactation (IUGR with slow postnatal growth, RR). Plasma LC-HRMS metabolomic fingerprints for 8 male rats per group, combined with multivariate statistical analysis (PLS-DA and HCA), were used to study the impact of IUGR and postnatal growth velocity on the offspring metabolism in early life (until weaning) and once they reached adulthood (8 months). Compared with CC rats, RR pups had clear-cut alterations in plasma metabolome during suckling, but none at adulthood; in contrast, in RC pups, alterations in metabolome were minimal in early life but more pronounced in the long run. In particular, our results pinpoint transient alterations in proline, arginine, and histidine in RR rats, compared to CC rats, and persistent differences in tyrosine and carnitine, compared to RC rats at adulthood. These findings suggest that the long-term deregulation in feeding behavior and fatty acid metabolism in IUGR rats depends on postnatal growth velocity
- Subjects :
- CARNITINE PALMITOYLTRANSFERASE
Intrauterine growth restriction
Biochemistry
Mass Spectrometry
Rats, Sprague-Dawley
chemistry.chemical_compound
0302 clinical medicine
GROWTH VELOCITY
Pregnancy
Lactation
GESTATION
ComputingMilieux_MISCELLANEOUS
2. Zero hunger
0303 health sciences
Fetal Growth Retardation
030219 obstetrics & reproductive medicine
PLACENTAL TRANSPORT
INTRAUTERINE GROWTH RESTRICTION
PLASMA
CATCH UP GROWTH
medicine.anatomical_structure
Prenatal Exposure Delayed Effects
Models, Animal
Female
medicine.drug
EXPRESSION
medicine.medical_specialty
Offspring
Weaning
Biology
MASS
METABOLOMICS
DIET
03 medical and health sciences
EARLY-LIFE
AMINO ACIDS
Internal medicine
Diet, Protein-Restricted
medicine
Metabolome
PREGNANCIES
Animals
Carnitine
030304 developmental biology
Fatty acid metabolism
Body Weight
General Chemistry
medicine.disease
Rats
Endocrinology
Animals, Newborn
chemistry
Multivariate Analysis
AMINO-ACID-TRANSPORT
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
CARNITINE
Subjects
Details
- Language :
- English
- ISSN :
- 15353893 and 15353907
- Database :
- OpenAIRE
- Journal :
- Journal of Proteome Research, Journal of Proteome Research, American Chemical Society, 2011, 10 (7), pp.3292-3302. ⟨10.1021/pr2003193⟩
- Accession number :
- edsair.doi.dedup.....3fb166455402658966086199f3a15240