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The possible impact of persistent virus infection on the function of the RNAi machinery in insects: a hypothesis
- Source :
- FRONTIERS IN PHYSIOLOGY, Frontiers in Physiology, Vol 4 (2013), Frontiers in Physiology
- Publication Year :
- 2013
- Publisher :
- Frontiers Media SA, 2013.
-
Abstract
- RNAi experiments in insects are characterized by great variability in efficiency; for instance beetles and locusts are very amenable to dsRNA-mediated gene silencing, while other insect groups, most notably lepidopterans, are more refractory to RNAi. Several factors can be forwarded that could affect the efficiency of RNAi, such as the composition and function of the intracellular RNAi machinery, the mechanism of dsRNA uptake, the presence of dsRNA- and siRNA-degrading enzymes and non-specific activation of the innate immune response. In this essay, we investigate the evidence whether persistent infection with RNA viruses could be a major factor that affects the response to exogenous dsRNA in insects. The occurrence of RNA viruses in different insect groups will be discussed, as well as several mechanisms by which viruses could interfere with the process of RNAi. Finally, the impact of RNA virus infection on the design of dsRNA-based insect control strategies will be considered. ispartof: Frontiers in Physiology vol:4 ispartof: location:Switzerland status: published
- Subjects :
- RNA virus
Physiology
viruses
DESERT LOCUST
DOUBLE-STRANDED-RNA
Dengue virus
medicine.disease_cause
lcsh:Physiology
RNA interference
Physiology (medical)
SMALL SILENCING RNAS
medicine
Gene silencing
insects
DENGUE VIRUS
Caenorhabditis elegans
Innate immune system
lcsh:QP1-981
FLOCK HOUSE VIRUS
biology
fungi
Biology and Life Sciences
RNA
biology.organism_classification
Virology
Hypothesis and Theory Article
SCHISTOCERCA-GREGARIA
Cell biology
Insects
persistent virus infection
BOMBYX-MORI
RNA silencing
CYTOPLASMIC POLYHEDROSIS-VIRUS
RNAi
innate immune response
ANTIVIRAL IMMUNITY
Pest Control
CAENORHABDITIS-ELEGANS
pest control
Subjects
Details
- ISSN :
- 1664042X
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Frontiers in Physiology
- Accession number :
- edsair.doi.dedup.....3f98d91c5e464b1cb88c4f640ae6bce4