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Pallidal stimulation for Parkinsonism: Improved brain activation during sequence learning
Pallidal stimulation for Parkinsonism: Improved brain activation during sequence learning
- Source :
- Annals of Neurology. 52:144-152
- Publication Year :
- 2002
- Publisher :
- Wiley, 2002.
-
Abstract
- We used 15 O-labeled water and positron emission tomography to assess the effect of deep brain stimulation of the internal globus pallidus on motor sequence learning in Parkinson's disease. Seven right-handed patients were scanned on and off stimulation while they were performing a motor sequence learning task and a kinematically matched motor execution reference task. The scans were performed after a 12-hour medication washout. Stimulation parameters were adjusted for maximal motor improvement; experimental task parameters were held constant across stimulation conditions. Internal globus pallidus stimulation improved motor ratings by 37% (p < 0.01). During the sequence learning task, stimulation improved performance as measured by several correct anticipatory movements (p < 0.01) and by verbal report (p < 0.001). Concurrent positron emission tomography imaging during learning demonstrated significant (p < 0.01) increases in brain activation with stimulation in the left dorsolateral prefrontal cortex, bilaterally in premotor cortex, and in posterior parietal and occipital association areas. Stimulation did not affect the activity of these regions during the performance of the motor execution reference task. These findings suggest that internal globus pallidus deep brain stimulation can enhance the activity of prefrontal cortico-striato-pallidothalamic loops and related transcortical pathways. Improved sequence learning with stimulation may be directly related to these functional changes.
- Subjects :
- Adult
Male
Deep brain stimulation
medicine.medical_treatment
Electric Stimulation Therapy
Stimulation
Motor Activity
Globus Pallidus
Central nervous system disease
Premotor cortex
Degenerative disease
Parkinsonian Disorders
medicine
Humans
Learning
Aged
medicine.diagnostic_test
Parkinsonism
Brain
Middle Aged
medicine.disease
medicine.anatomical_structure
nervous system
Neurology
Positron emission tomography
Female
Neurology (clinical)
Sequence learning
Psychology
Neuroscience
Tomography, Emission-Computed
Subjects
Details
- ISSN :
- 15318249 and 03645134
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Annals of Neurology
- Accession number :
- edsair.doi.dedup.....3f9699b29b1b07a70d3cf4dc933dc2db
- Full Text :
- https://doi.org/10.1002/ana.10261