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Intracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal: A case report and review of the literature
- Source :
- Current Problems in Cancer: Case Reports, Vol 4, Iss, Pp 100130-(2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Adenoid cystic carcinoma of the external auditory canal is very rare tumour. Its course is mainly indolent, and is characterised by intracranial extension, high rates of loco-regional relapse, and distant metastasis, which culminates in a slow detrimental disease course, eventually leading to death. The main therapeutic modalities are local therapies such as surgery and/or radiotherapy. Systemic treatment has never achieved good clinical outcomes in this setting. Here, we describe the case report of a 50-year-old female, diagnosed with an adenoid cystic carcinoma of the right external auditory canal in 2003. The patient developed multiples recurrences, including an extensive intracerebral progression associated with radio necrosis, for which systemic therapy with bevacizumab and epirubicin was initiated. This achieved an intracerebral partial response with clinical benefit, allowing the rapid tapering of corticosteroid treatment. This case report highlights epirubicin in combination with bevacizumab as a therapeutic option for heavily treated patients with adenoid cystic carcinoma and intracranial involvement.
- Subjects :
- medicine.medical_specialty
Bevacizumab
Adenoid cystic carcinoma
medicine.medical_treatment
Corticosteroid treatment
Systemic therapy
Auditory canal
Right external auditory canal
Case report
medicine
RC254-282
General Environmental Science
Epirubicin
External auditory canal
business.industry
General Engineering
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Radiation therapy
General Earth and Planetary Sciences
Radiology
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 26666219
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Current Problems in Cancer: Case Reports
- Accession number :
- edsair.doi.dedup.....3f8e6f3f0d567ffa39bec88f1270605e