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TRIB1 rs17321515 and rs2954029 gene polymorphisms increase the risk of non-alcoholic fatty liver disease in Chinese Han population
- Source :
- Lipids in Health and Disease, Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-7 (2019)
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Background Dysregulation of the lipid homeostasis is an independent risk factor for non-alcoholic fatty liver disease (NAFLD). Some studies had demonstrated that TRIB1 gene polymorphisms affect the plasma lipids metabolism, but no related data was available for TRIB1 gene polymorphisms in the lipids metabolism in Chinses Han population. The present study was conducted to investigate the association between TRIB1 gene polymorphisms (rs17321515 and rs2954029) and the risk of NAFLD in Chinese Han population and their effects on serum lipid profiles. Patients and methods TRIB1 rs17321515 and rs2954029 gene polymorphisms were genotyped using the polymerase chain reaction (PCR) in B-type ultrasonography-proven NAFLD patients (n = 146) and healthy controls (n = 175). Serum lipid profiles were determined using biochemical methods. Statistical analyses were performed using SPSS 22.0 statistical software. Results The allele distributions of TRIB1 rs17321515 A and rs2954029 A were significant different between the NAFLD patients and healthy controls (P = 0.026, P = 0.045, respectively). The genotype distribution of TRIB1 rs17321515 was significant different between NAFLD patients and healthy controls (P = 0.038). The TRIB1 rs17321515 GA + AA genotype and TRIB1 rs2954029 TA + AA genotype markedly increase the NAFLD risk (OR = 1.885; 95%CI: 1.157–3.070; OR = 1.627; 95%CI: 1.011–2.619, respectively), after adjusted for age, gender, and body mass index, the NAFLD risk still significant (OR = 2.240; 95%CI: 1.196–4.197; OR = 2.050; 95%CI: 1.110–3.786, respectively). In addition, TRIB1 rs17321515 A and rs2954029 A carriers possess the higher lipid profiles in the included subjects. Conclusions TRIB1 rs17321515 and rs2954029 were significant associated with the risk of NAFLD in Chinese Han population. The rs17321515 A and rs2954029 A allele increases the serum lipid profiles in Chinese Han population.
- Subjects :
- Male
medicine.medical_specialty
Clinical chemistry
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
030209 endocrinology & metabolism
Clinical nutrition
Protein Serine-Threonine Kinases
030204 cardiovascular system & hematology
Polymorphism, Single Nucleotide
Gastroenterology
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Endocrinology
Asian People
Gene Frequency
Non-alcoholic Fatty Liver Disease
Internal medicine
Genotype
medicine
Humans
Genetic Predisposition to Disease
Allele
Risk factor
lcsh:RC620-627
Aged
business.industry
Research
TRIB1
Biochemistry (medical)
Fatty liver
Intracellular Signaling Peptides and Proteins
Middle Aged
Lipid Metabolism
medicine.disease
lcsh:Nutritional diseases. Deficiency diseases
Case-Control Studies
Female
Polymorphism, lipids metabolism
business
Body mass index
Lipidology
Subjects
Details
- ISSN :
- 1476511X
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Lipids in Health and Disease
- Accession number :
- edsair.doi.dedup.....3f89e33f28c1028e39325b35064f1822