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Optimizing the size and surface properties of polyethylene glycol (PEG)–gold nanoparticles by intense x-ray irradiation
- Source :
- Journal of Physics D: Applied Physics. 41:195301
- Publication Year :
- 2008
- Publisher :
- IOP Publishing, 2008.
-
Abstract
- The polyethylene glycol (PEG) modified gold nanoparticle complex was synthesized by a one-solution synchrotron x-ray irradiation method. The impact on the structure and morphology of the gold nanoparticles of process parameters such as the PEG molecular weight, the PEG/gold molar ratio and the x-ray dosage were investigated. The size of PEG modified gold particles was found to decrease with increasing PEG addition and x-ray dosage. With the capability to monitor the absorption spectra in situ during the fast synthesis process, this opens the way to accurate control of the size and distribution. PEG chains with an intermediate length (MW6000) were found optimal for size control and colloidal stability in biologically relevant media. Our x-ray synthesized PEG-gold nanoparticles could find interesting applications in nanoparticle-enhanced x-ray tumour imaging and therapy.
- Subjects :
- Materials science
Nanostructure
Acoustics and Ultrasonics
Targeted Drug-Delivery
Colloidal Gold
Nanoparticle
Nanotechnology
macromolecular substances
Polyethylene glycol
CIBM-PC
Mice
chemistry.chemical_compound
Biodistribution
Gold Compounds
PEG ratio
Gold Nanoparticles
Polymer
chemistry.chemical_classification
technology, industry, and agriculture
Condensed Matter Physics
Peg
Contrast Agent
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
chemistry
Chemical engineering
Colloidal gold
Adsorption
Particle size
In-Vivo
Subjects
Details
- ISSN :
- 13616463 and 00223727
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Journal of Physics D: Applied Physics
- Accession number :
- edsair.doi.dedup.....3f7f08c82d46c1054d194f7f6ab4f366