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MicroRNA-92a as a Potential Biomarker in Diagnosis of Colorectal Cancer: A Systematic Review and Meta-Analysis
- Source :
- PLoS ONE, PLoS ONE, Vol 9, Iss 2, p e88745 (2014)
- Publication Year :
- 2014
- Publisher :
- Public Library of Science (PLoS), 2014.
-
Abstract
- Introduction Previous studies demonstrated that MicroRNA-92a (miR-92a) was significantly differential expressed between colorectal cancer (CRC) patients and control cohorts, which provide timely relevant evidence for miR-92a as a novel promising biomarker in the colorectal cancer patients. This meta-analysis aimed to evaluate potential diagnostic value of plasma miR-92a. Methods Relevant literatures were collected in PubMed, Embase, Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI) and Technology of Chongqing (VIP), and Wan Fang Data. Sensitivity, specificity and diagnostic odds ratio (DOR) for miR-92a in the diagnosis of CRC were pooled using random effects models. Summary receiver operating characteristic (SROC) curve analysis and the area under the curve (AUC) were used to estimate the overall test performance. Results This Meta-analysis included six studies with a total of 521 CRC patients and 379 healthy controls. For miR-92a, the pooled sensitivity, specificity and DOR to predict CRC patients were 76% (95% confidence interval [CI]: 72%–79%), 64% (95% confidence interval [CI]: 59%–69%) and 8.05 (95% CI: 3.50–18.56), respectively. In addition, the AUC of miR-92a in diagnosis CRC is 0.7720. Conclusions MicroRNA-92a might be a novel potential biomarker in the diagnosis of colorectal cancer, and more studies are needed to highlight the theoretical strengths.
- Subjects :
- Oncology
Health Screening
Colorectal cancer
lcsh:Medicine
Bioinformatics
Biochemistry
Nucleic Acids
Gastrointestinal Cancers
Pathology
Medicine
lcsh:Science
Multidisciplinary
Area under the curve
Middle Aged
Meta-analysis
Regression Analysis
Biomarker (medicine)
Public Health
Colorectal Neoplasms
Research Article
Test Evaluation
medicine.medical_specialty
Systematic Reviews
Clinical Research Design
Gastroenterology and Hepatology
Genetic Heterogeneity
Diagnostic Medicine
Internal medicine
Gastrointestinal Tumors
Biomarkers, Tumor
Cancer Detection and Diagnosis
Humans
Biology
Aged
Receiver operating characteristic
business.industry
lcsh:R
Cancers and Neoplasms
Publication bias
medicine.disease
Confidence interval
MicroRNAs
ROC Curve
Diagnostic odds ratio
RNA
lcsh:Q
Meta-Analyses
business
Publication Bias
Biomarkers
General Pathology
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....3f7ce4695f1e7aaac25dca1e4fb441f6