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Long-term biological variation of high-sensitivity cardiac troponin T using minimal important differences and reference change values in stable outpatients with cardiovascular disease
- Source :
- Clinical biochemistry. 67
- Publication Year :
- 2018
-
Abstract
- Objective To evaluate the long term biological variation of high-sensitivity cardiac troponin T (hs-cTnT) in stable outpatients with cardiovascular disease (CVD). Methods After applying 8 exclusion criteria to 965 patients, hs-cTnT was measured at index visit and at a 12-month interval in 169 stable outpatients presenting for routine follow-up visits for any CVD. Stability was defined as absence of any endpoint within the follow-up period. Reference change values (RCVs) and minimal important differences (MIDs) were determined to assess biological variation of hs-cTnT. Results MID and RCV for the 12 months interval in patients were 3.8 ng/L or 44.2%, respectively. MID and transformed MID values were lower than the corresponding RCV with a value of 5.1 ng/L for the transformed RCV and 28.1% for the transformed MID. Similar patterns were shown in different subgroups as sex, age, and renal function . We observed a baseline hs-cTnT value dependent change of MID and RCV with increasing values for MID and decreasing values for RCV which converge to stable values between a baseline hs-cTNT value of 11 to 25 ng/L. Conclusions Biological variation of hs-cTnT over 12 months in stable outpatients depends on the concentration at index visit, and is consistent among important prespecified subgroups. MID shows a low biovariability over 12 months. Clinical Trials Identifier: NCT01954303
- Subjects :
- 030213 general clinical medicine
medicine.medical_specialty
Cardiac troponin
Time Factors
Clinical Biochemistry
Renal function
Disease
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Troponin T
Internal medicine
Biological variation
Outpatients
medicine
Humans
In patient
Longitudinal Studies
Aged
Aged, 80 and over
business.industry
General Medicine
Middle Aged
High Sensitivity Troponin T
Term (time)
Cardiovascular Diseases
Cardiology
business
Subjects
Details
- ISSN :
- 18732933
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Clinical biochemistry
- Accession number :
- edsair.doi.dedup.....3f7bcb548b382c7843f79b9403bc8903