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Dopaminergic medication shifts the balance between going and stopping in Parkinson’s disease
- Source :
- Neuropsychologia, 109, 262-269. Elsevier
- Publication Year :
- 2018
-
Abstract
- The present behavioral study delineates the impact of Parkinson's disease (PD) and of dopaminergic medication on action control over voluntary behavior. Previous studies reported either prolonged responding or stopping latencies in PD compared to healthy controls (HC). Few studies investigated the effects of dopaminergic medication on these processes concurrently. We administered a stop-change task, an extended version of the stop task, that required (i) speeded responding to a go signal (i.e., going), (ii) inhibiting ongoing motor responses (i.e., stopping), and (iii) changing to an alternative response. PD performance (n = 33) was collected once during regular dopaminergic medication conditions (On state) and once after a medication washout period (Off state). A group of age-matched HC (n = 21) performed the stop-change task once. Response latencies to go signals were comparable between HC and PD Off, indicative of unimpaired going. Compared to HC, PD Off showed prolonged stopping latencies. Within the clinical group, stopping latencies significantly improved after taking dopaminergic medication. Interestingly, the shorter stopping latencies observed in the On state were paralleled by longer response latencies to go signals. The degree of the inhibition improvement observed in the medication state was correlated with the degree of response slowing. Change RT did not vary between groups or between medication states. These patterns of results are discussed in terms of a tradeoff between going versus stopping of motor responses in PD patients. Shifts of this tradeoff seem to be driven by dopaminergic medication, which has potential clinical implications.
- Subjects :
- Male
medicine.medical_specialty
Parkinson's disease
Dopamine
Cognitive Neuroscience
Dopamine Agents
Experimental and Cognitive Psychology
Motor Activity
Audiology
Washout period
050105 experimental psychology
Self-Control
Executive Function
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Behavioral study
Inhibitory control
Reaction Time
medicine
Humans
0501 psychology and cognitive sciences
Balance (ability)
05 social sciences
Dopaminergic
Action control
Parkinson Disease
Middle Aged
medicine.disease
Inhibition, Psychological
Female
Psychology
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 00283932
- Database :
- OpenAIRE
- Journal :
- Neuropsychologia, 109, 262-269. Elsevier
- Accession number :
- edsair.doi.dedup.....3f7a38936143c9a5d931c3de8cf503da