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Recombination Monophosphoryl Lipid A-Derived Vacosome for the Development of Preventive Cancer Vaccines
- Source :
- ACS Applied Materials & Interfaces
- Publication Year :
- 2020
- Publisher :
- American Chemical Society, 2020.
-
Abstract
- Recently, there has been an increasing interest for utilizing the host immune system to fight against cancer. Moreover, cancer vaccines, which can stimulate the host immune system to respond to cancer in the long term, are being investigated as a promising approach to induce tumor-specific immunity. In this work, we prepared an effective cancer vaccine (denoted as vacosome) by reconstructing the cancer cell membrane, monophosphoryl lipid A as a toll-like receptor 4 agonist, and egg phosphatidylcholine. The vacosome triggered and enhanced bone marrow dendritic cell maturation as well as stimulated the antitumor response against breast cancer 4T1 cells in vitro. Furthermore, an immune memory was established in BALB/c mice after three-time preimmunization with the vacosome. After that, the immunized mice showed inhibited tumor growth and prolonged survival period (longer than 50 days). Overall, our results demonstrate that the vacosome can be a potential candidate for clinical translation as a cancer vaccine.
- Subjects :
- liposomes
Materials science
Surface Properties
medicine.medical_treatment
3122 Cancers
Monophosphoryl Lipid A
cancer cell membrane
chemical and pharmacologic phenomena
Breast Neoplasms
02 engineering and technology
IMMUNITY
Cancer Vaccines
03 medical and health sciences
DELIVERY
Mice
Immune system
Cancer immunotherapy
Immunity
Cell Line, Tumor
medicine
Animals
General Materials Science
Particle Size
030304 developmental biology
Cell Proliferation
0303 health sciences
Liposome
Mice, Inbred BALB C
318 Medical biotechnology
cancer immunotherapy
fungi
MEMORY
Cell Membrane
food and beverages
Cancer
biochemical phenomena, metabolism, and nutrition
021001 nanoscience & nanotechnology
medicine.disease
3. Good health
Lipid A
317 Pharmacy
Immunology
CELLS
bacteria
0210 nano-technology
ADJUVANT SYSTEM
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19448252 and 19448244
- Volume :
- 12
- Issue :
- 40
- Database :
- OpenAIRE
- Journal :
- ACS Applied Materials & Interfaces
- Accession number :
- edsair.doi.dedup.....3f646b2b956f4c49e00a03b9bff6af1a