Back to Search
Start Over
Keratin K15 as a Biomarker of Epidermal Stem Cells
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 14, Iss 10, Pp 19385-19398 (2013)
- Publication Year :
- 2013
- Publisher :
- MDPI AG, 2013.
-
Abstract
- Keratin 15 (K15) is type I keratin protein co-expressed with the K5/K14 pair present in the basal keratinocytes of all stratified epithelia. Although it is a minor component of the cytoskeleton with a variable expression pattern, nonetheless its expression has been reported as a stem cell marker in the bulge of hair follicles. Conversely, suprabasal expression of K15 has also been reported in both normal and diseased tissues, which is inconsistent with its role as a stem cell marker. Our recently published work has given evidence of the molecular pathways that seem to control the expression of K15 in undifferentiated and differentiated cells. In this article, we have critically reviewed the published work to establish the reliability of K15 as an epidermal stem cell marker.
- Subjects :
- intermediate filaments
Cellular differentiation
Review
Biology
Stem cell marker
Catalysis
lcsh:Chemistry
Inorganic Chemistry
Keratin
Animals
Humans
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Molecular Biology
Spectroscopy
chemistry.chemical_classification
pluripotent cells
integumentary system
Keratin-15
keratinocyte differentiation
Stem Cells
Organic Chemistry
transit-amplifying cells
basal keratinocytes
General Medicine
Computer Science Applications
Cell biology
Keratin 5
lcsh:Biology (General)
lcsh:QD1-999
chemistry
Keratin 7
Keratin 8
Epidermis
Stem cell
Biomarkers
Adult stem cell
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....3f57a0123e45f20d22d85b6ca7a2439f