Back to Search
Start Over
Carzelesin phase II study in advanced breast, ovarian, colorectal, gastric, head and neck cancer, non-Hodgkin's lymphoma and malignant melanoma: a study of the EORTC early clinical studies group (ECSG)
- Source :
- Cancer Chemotherapy and Pharmacology, 167-171, STARTPAGE=167;ENDPAGE=171;ISSN=0344-5704;TITLE=Cancer Chemotherapy and Pharmacology, Cancer Chemotherapy & Pharmacology, 46, 167-171. Springer-Verlag, Cancer Chemotherapy and Pharmacology, 46, pp. 167-171, Cancer chemotherapy and pharmacology
- Publication Year :
- 2000
-
Abstract
- PURPOSE: In a phase II trial, the activity of carzelesin, a cyclopropylpyrroloindole prodrug analog, was assessed. PATIENTS AND METHODS: Carzelesin was used as second- or third-line chemotherapy in patients with breast, ovarian, head and neck cancer and non-Hodgkin's lymphoma, and as first-line chemotherapy in patients with colorectal and gastric cancer and melanoma. The drug was given as a bolus infusion at a 4-weekly dose of 150 microg/m2. A total of 140 patients were entered and a total of 285 courses were administered. RESULTS: In general, the compound was well tolerated. Myelotoxicity was the most common toxicity. Grade 3 and 4 leukopenia was observed in 18.6% of the courses, neutropenia in 20.3%, thrombocytopenia in 16.2% and anemia in 8.7%. Double nadirs were seen in a total of 41 courses for neutrophils, in 40 for leukocytes and in 3 for platelets. Non-hematological toxicity was very mild. Only one partial response in a patient with melanoma was seen. CONCLUSIONS: At this dose and schedule carzelesin did not yield activity in the types of tumors studied. Cancer Chemother Pharmacol
- Subjects :
- Oncology
Male
Cancer Research
Indoles
Lymphoma
medicine.medical_treatment
Phases of clinical research
Toxicology
Ovarian neoplasms
Breast cancer
hemic and lymphatic diseases
Neoplasms
Antineoplastic agents
Solid tumors
Melanoma/drug therapy
Pharmacology (medical)
Prodrugs
Head and neck cancer
Infusions, Intravenous
Bone marrow depression
Melanoma
Priority journal
Ovarian Neoplasms
Carzelesin
Leukopenia
Lymphoma, Non-Hodgkin
Ovarian Neoplasms/drug therapy
Colorectal Neoplasms/drug therapy
Blood toxicity
Middle Aged
Clinical trial
Head and Neck Neoplasms
Nonhodgkin lymphoma
Female
medicine.symptom
Intravenous
Colorectal Neoplasms
Antineoplastic Agents/administration & dosage/adverse effects/*therapeutic use
Human
Adult
Infusions
medicine.medical_specialty
Neutropenia
Fever
Ovary cancer
Stomach cancer
Stomach neoplasms
Antineoplastic Agents
Breast Neoplasms
Major clinical study
Bone marrow toxicity
Prodrugs/adverse effects/*therapeutic use
Head and neck neoplasms
Article
Colorectal neoplasms
Benzofurans/administration & dosage/adverse effects/*therapeutic use
Covalent bond
Lymphoma, Non-Hodgkin/drug therapy
Experimental diagnostics and therapy of malignancies
Duocarmycins
Breast Neoplasms/drug therapy
SDG 3 - Good Health and Well-being
Stomach Neoplasms
Advanced cancer
Internal medicine
medicine
Humans
Phase 2 clinical trial
Aged
Benzofurans
Neoplasm Staging
Indoles/administration & dosage/adverse effects/*therapeutic use
Pharmacology
Non-hodgkin
Chemotherapy
Toxicity
business.industry
Cancer
Head and Neck Neoplasms/drug therapy
Neoplasms/*drug therapy/pathology
medicine.disease
Thrombocytopenia
Colorectal cancer
Surgery
Non-Hodgkin's lymphoma
Stomach Neoplasms/drug therapy
Breast neoplasms
business
Subjects
Details
- ISSN :
- 03445704
- Volume :
- 46
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cancer chemotherapy and pharmacology
- Accession number :
- edsair.doi.dedup.....3f47bfa16e1c9334d4850652b4442cf3