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A bimodal theranostic nanodelivery system based on [graphene oxide-chlorogenic acid-gadolinium/gold] nanoparticles
- Source :
- PLoS ONE, Vol 13, Iss 7, p e0200760 (2018), PLoS ONE
- Publication Year :
- 2018
- Publisher :
- Public Library of Science (PLoS), 2018.
-
Abstract
- We have synthesized a bimodal theranostic nanodelivery system (BIT) that is based on graphene oxide (GO) and composed of a natural chemotherapeutic agent, chlorogenic acid (CA) used as the anticancer agent, while gadolinium (Gd) and gold nanoparticles (AuNPs) were used as contrast agents for magnetic resonance imaging (MRI) modality. The CA and Gd guest agents were simultaneously loaded on the GO nanolayers using chemical interactions, such as hydrogen bonding and π-π non-covalent interactions to form GOGCA nanocomposite. Subsequently, the AuNPs were doped on the surface of the GOGCA by means of electrostatic interactions, which resulted in the BIT. The physico-chemical studies of the BIT affirmed its successful development. The X-ray diffractograms (XRD) collected of the various stages of BIT synthesis showed the successive development of the hybrid system, while 90% of the chlorogenic acid was released in phosphate buffer solution (PBS) at pH 4.8. This was further reaffirmed by the in vitro evaluations, which showed stunted HepG2 cancer cells growth against the above 90% cell growth in the control cells. A reverse case was recorded for the 3T3 normal cells. Further, the acquired T1-weighted image of the BIT doped samples obtained from the MRI indicated contrast enhancement in comparison with the plain Gd and water references. The abovementioned results portray our BIT as a promising future chemotherapeutic for anticancer treatment with diagnostic modalities.
- Subjects :
- Cell Lines
Gadolinium
Cancer Treatment
Contrast Media
Metal Nanoparticles
lcsh:Medicine
Nanoparticle
Reflection
02 engineering and technology
Physical Chemistry
01 natural sciences
Theranostic Nanomedicine
Diagnostic Radiology
Nanocomposites
Nanomaterials
law.invention
Mice
chemistry.chemical_compound
X-Ray Diffraction
law
Medicine and Health Sciences
Nanotechnology
lcsh:Science
Multidisciplinary
Radiology and Imaging
Physics
Temperature
Classical Mechanics
Oxides
3T3 Cells
Hep G2 Cells
Hydrogen-Ion Concentration
021001 nanoscience & nanotechnology
Magnetic Resonance Imaging
Chemistry
Oncology
Colloidal gold
Physical Sciences
Engineering and Technology
Graphite
Biological Cultures
Chlorogenic Acid
0210 nano-technology
Research Article
Imaging Techniques
Surface Properties
Materials Science
Oxide
chemistry.chemical_element
Structural Characterization
Antineoplastic Agents
Research and Analysis Methods
010402 general chemistry
Microscopy, Electron, Transmission
Chlorogenic acid
Diagnostic Medicine
Animals
Humans
Materials by Attribute
Nanocomposite
Chemical Bonding
Graphene
lcsh:R
Hydrogen Bonding
0104 chemical sciences
Kinetics
chemistry
Nanoparticles
lcsh:Q
Cultured Fibroblasts
Gold
Drug Screening Assays, Antitumor
Nuclear chemistry
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....3f47658485b6d9dbe9f35fcd7a1397a8