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RNA Synthesis by in Vitro Selected Ribozymes for Recreating an RNA World
- Source :
- Martin, LL; Unrau, PJ; & Müller, UF. (2015). RNA synthesis by in vitro selected ribozymes for recreating an RNA world. Life, 5(1), 247-268. doi: 10.3390/life5010247. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/7fc6h3xj, Life (Basel, Switzerland), vol 5, iss 1, Life, Vol 5, Iss 1, Pp 247-268 (2015), Life
- Publication Year :
- 2015
- Publisher :
- MDPI AG, 2015.
-
Abstract
- © 2014 by the authors; licensee MDPI, Basel, Switzerland. The RNA world hypothesis states that during an early stage of life, RNA molecules functioned as genome and as the only genome-encoded catalyst. This hypothesis is supported by several lines of evidence, one of which is the in vitro selection of catalytic RNAs (ribozymes) in the laboratory for a wide range of reactions that might have been used by RNA world organisms. This review focuses on three types of ribozymes that could have been involved in the synthesis of RNA, the core activity in the self-replication of RNA world organisms. These ribozyme classes catalyze nucleoside synthesis, triphosphorylation, and the polymerization of nucleoside triphosphates. The strengths and weaknesses regarding each ribozyme’s possible function in a self-replicating RNA network are described, together with the obstacles that need to be overcome before an RNA world organism can be generated in the laboratory.
- Subjects :
- Riboswitch
RNA world
Review
Computational biology
01 natural sciences
origin of life
General Biochemistry, Genetics and Molecular Biology
ribozyme
03 medical and health sciences
Sense (molecular biology)
Genetics
lcsh:Science
Ecology, Evolution, Behavior and Systematics
Ligase ribozyme
030304 developmental biology
0303 health sciences
biology
010405 organic chemistry
Ribozyme
Paleontology
RNA
0104 chemical sciences
Infectious Diseases
Space and Planetary Science
RNA editing
RNA splicing
biology.protein
lcsh:Q
Generic health relevance
Mammalian CPEB3 ribozyme
Subjects
Details
- ISSN :
- 20751729
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Life
- Accession number :
- edsair.doi.dedup.....3f3d318b58232e6188e85b8050a409bd