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Honeycomb structural composite polymer network of gelatin and functional cellulose ester for controlled release of omeprazole
- Source :
- International Journal of Biological Macromolecules. 105:1644-1653
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- The functionalized cellulose ester MCN was firstly synthesized and used to cross-link gelatin by amidation between -NH2 in gelatin and active ester groups in MCN to form a composite polymer network Gel-MCN, which was confirmed by Van Slyke method, FTIR, XRD and TGA-DTG spectra. The model drug omeprazole was loaded in Gel-MCN composites mainly by electrostatic interaction and hydrogen bonds, which were certified by FTIR, XRD and TGA-DSC. Thermal stability, anti-biodegradability, mechanical property and surface hydrophobicity of the composites with different cross-linking extents and drug loading were systematically investigated. SEM images demonstrated the honeycomb structural cells of cross-linked gelatin networks and this ensured drug entrapment. The drug release mechanism was dominated by a combined effect of diffusion and degradation, and the release rate decreased with cross-linking degree increased. The developed drug delivery system had profound significance in improving pesticide effect and bioavailability of drugs.
- Subjects :
- food.ingredient
02 engineering and technology
010402 general chemistry
01 natural sciences
Biochemistry
Gelatin
chemistry.chemical_compound
food
Drug Stability
Structural Biology
Organic chemistry
Thermal stability
Cellulose
Fourier transform infrared spectroscopy
Molecular Biology
Drug Carriers
Hydrogen bond
Temperature
Esters
General Medicine
021001 nanoscience & nanotechnology
Controlled release
0104 chemical sciences
Microcrystalline cellulose
chemistry
Chemical engineering
Delayed-Action Preparations
Drug delivery
0210 nano-technology
Omeprazole
Subjects
Details
- ISSN :
- 01418130
- Volume :
- 105
- Database :
- OpenAIRE
- Journal :
- International Journal of Biological Macromolecules
- Accession number :
- edsair.doi.dedup.....3f3c0833386f752e764b2a8cfb5b0cac