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Characterization of Autism Spectrum Disorder across the Age Span by Intrinsic Network Patterns
- Source :
- Brain Topography. 32:461-471
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Autism spectrum disorder (ASD) is characterized by abnormal functional organization of brain networks, which may underlie the cognitive and social impairments observed in affected individuals. The present study characterizes unique intrinsic connectivity within- and between- neural networks in children through to adults with ASD, relative to controls. Resting state fMRI data were analyzed in 204 subjects, 102 with ASD and 102 age- and sex-matched controls (ages 7-40 years), acquired on a single scanner. ASD was assessed using the autism diagnostic observation schedule (ADOS). BOLD correlations were calculated between 47 regions of interest, spanning seven resting state brain networks. Partial least squares (PLS) analyses evaluated the association between connectivity patterns and ASD diagnosis as well as ASD severity scores. PLS demonstrated dissociable connectivity patterns in those with ASD, relative to controls. Similar patterns were observed in the whole cohort and in a subgroup analysis of subjects under 18 years of age. Greater inter-network connectivity was seen in ASD with greater intra-network connectivity in controls. In conclusion, stronger inter-network and weaker intra-network resting state-fMRI BOLD correlations characterize ASD and may differentiate control and ASD cohorts. These findings are relevant to understanding ASD as a disruption of network topology.
- Subjects :
- Adult
Male
medicine.medical_specialty
Neurology
Adolescent
genetic structures
Autism Spectrum Disorder
Subgroup analysis
Audiology
behavioral disciplines and activities
050105 experimental psychology
Autism Diagnostic Observation Schedule
Young Adult
03 medical and health sciences
0302 clinical medicine
mental disorders
medicine
Humans
0501 psychology and cognitive sciences
Radiology, Nuclear Medicine and imaging
Child
Association (psychology)
Brain Mapping
Radiological and Ultrasound Technology
Resting state fMRI
Functional Neuroimaging
05 social sciences
Brain
Cognition
medicine.disease
Magnetic Resonance Imaging
Autism spectrum disorder
Case-Control Studies
Cohort
Female
Neurology (clinical)
Anatomy
Psychology
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15736792 and 08960267
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Brain Topography
- Accession number :
- edsair.doi.dedup.....3f3b213524b8877b877f68298a2a957d