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No association between N7-methyldeoxyguanosine and 8-oxodeoxyguanosine levels in human lymphocyte DNA
- Source :
- Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 600:125-130
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- To examine associations between two different classes of DNA damage that can occur through endogenous processes or exogenous exposures such as smoking, N7-methyldeoxyguanosine (N7-MedG) and 8-oxodeoxyguanosine (8-oxodG) levels were measured in lymphocyte DNA from 22 bronchoscopy patients. 8-OxodG and N7-MedG was detected in 100% and 91% of samples, respectively with 8-oxodG levels being approx 20 times higher (mean 8.39+/-3.578-oxodG/10(6)dG versus 0.41+/-0.33 N7-MedG/10(6) dG) which provides an indication of the relative importance of the agents that induce oxidative DNA damage or alkylation damage. The sources of these genotoxic lesions remain to be established but N7-MedG and 8-oxodG levels were not correlated (r(2)
- Subjects :
- Male
DNA damage
DNA repair
Health, Toxicology and Mutagenesis
Lymphocyte
Endogeny
Biology
chemistry.chemical_compound
Genetics
medicine
Humans
Lymphocytes
Molecular Biology
Aged
Aged, 80 and over
chemistry.chemical_classification
Reactive oxygen species
Smoking
Deoxyguanosine
8-Hydroxy-2'-deoxyguanosine
DNA
Metabolism
Middle Aged
Molecular biology
medicine.anatomical_structure
chemistry
8-Hydroxy-2'-Deoxyguanosine
Female
DNA Damage
Subjects
Details
- ISSN :
- 00275107
- Volume :
- 600
- Database :
- OpenAIRE
- Journal :
- Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
- Accession number :
- edsair.doi.dedup.....3f3394e358d6150706e3c6f4e6b6593a