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Aldosterone paradox: differential regulation of ion transport in distal nephron
- Source :
- Physiology (Bethesda Md.)
- Publication Year :
- 2011
-
Abstract
- The mechanisms through which aldosterone promotes apparently opposite effects like salt reabsorption and K+secretion remain poorly understood. The identification, localization, and physiological analysis of ion transport systems in distal nephron have revealed an intricate network of interactions between several players, revealing the complex mechanism behind the aldosterone paradox. We review the mechanisms involved in differential regulation of ion transport that allow the fine tuning of salt and K+balance.
- Subjects :
- medicine.medical_specialty
Physiology
030232 urology & nephrology
Sodium Chloride
Distal nephron
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Animals
Humans
Secretion
Kidney Tubules, Distal
Aldosterone
Ion transporter
030304 developmental biology
0303 health sciences
Ion Transport
Extramural
Reabsorption
Differential regulation
Endocrinology
chemistry
Biophysics
Potassium
Kidney tubules
Subjects
Details
- ISSN :
- 15489221
- Volume :
- 26
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Physiology (Bethesda, Md.)
- Accession number :
- edsair.doi.dedup.....3f316173b43767a351d53edc09e892e3