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Diastolic Dysfunction Is a Risk of Perioperative Myocardial Injury Assessed by High-Sensitivity Cardiac Troponin T in Elderly Patients Undergoing Non-Cardiac Surgery
- Source :
- Circulation Journal. 82:775-782
- Publication Year :
- 2018
- Publisher :
- Japanese Circulation Society, 2018.
-
Abstract
- BACKGROUND High-sensitivity cardiac troponin T (hs-cTnT) is useful for detecting myocardial injury and is expected to become a prognostic marker in patients undergoing non-cardiac surgery. The aim of this pilot study evaluating the efficacy of β-blocker therapy in a perioperative setting (MAMACARI study) was to assess perioperative myocardial injury (PMI) in elderly patients with preserved ejection fraction (EF) undergoing non-cardiac surgery.Methods and Results:In this prospective observational cohort study of 151 consecutive patients with preserved EF and aged >60 years who underwent non-cardiac surgery, serum levels of hs-cTnT were measured before and on postoperative days 1 and 3 after surgery. PMI was defined as postoperative hs-cTnT >0.014 ng/mL and relative hs-cTnT change ≥20%. A total of 36 (23.8%) of the patients were diagnosed as having PMI. The incidence of a composite of cardiovascular events within 30 days after surgery, including myocardial infarction, stroke, worsening heart failure, atrial fibrillation and pulmonary embolism, was significantly higher in patients with PMI than in patients without PMI (odds ratio (OR) 9.25, P
- Subjects :
- Male
medicine.medical_specialty
Myocardial Ischemia
Diastole
Pilot Projects
030204 cardiovascular system & hematology
Ventricular Dysfunction, Left
03 medical and health sciences
0302 clinical medicine
Troponin T
Risk Factors
Internal medicine
medicine
Humans
Prospective Studies
030212 general & internal medicine
Myocardial infarction
Perioperative Period
Stroke
Aged
Aged, 80 and over
Ejection fraction
business.industry
Stroke Volume
Atrial fibrillation
General Medicine
Perioperative
medicine.disease
Cardiovascular Diseases
Echocardiography
Surgical Procedures, Operative
Heart failure
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 13474820 and 13469843
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- Circulation Journal
- Accession number :
- edsair.doi.dedup.....3f1f3760528cf3311a96042b4e8d010b