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Development of the Thymus Requires Signaling Through the Fibroblast Growth Factor Receptor R2-IIIb
- Source :
- The Journal of Immunology. 167:1954-1961
- Publication Year :
- 2001
- Publisher :
- The American Association of Immunologists, 2001.
-
Abstract
- Mice deficient for fibroblast growth factor (Fgf)R2-IIIb show a block in thymic growth after embryonic day 12.5, a stage that just precedes its detection in thymic epithelial cells. Fgf7 and Fgf10, the main ligands for FgfR2-IIIb, are expressed in the mesenchyme surrounding the thymic epithelial primordium, and Fgf10-deficient mice also exhibit impaired thymic growth. Hence, Fgf signaling is essential for thymic epithelial proliferation. In addition to the proliferative block, most thymic epithelial cells fail to progress from an immature cytokeratin 5-positive to a cytokeratin 5-negative phenotype. Nevertheless, sufficient epithelial cell differentiation occurs in the severely hypoplastic thymus to allow the development of CD4/CD8-double-positive thymocytes and a very small number of single-positive thymocytes expressing TCRs.
- Subjects :
- Male
medicine.medical_specialty
Fibroblast Growth Factor 7
T-Lymphocytes
Mesenchyme
Cellular differentiation
Immunology
Thymus Gland
Biology
Fibroblast growth factor
Epithelium
Mice
Cytokeratin
Culture Techniques
Internal medicine
medicine
Animals
Paired Box Transcription Factors
Protein Isoforms
Immunology and Allergy
Receptor, Fibroblast Growth Factor, Type 2
Epithelial cell differentiation
Mice, Knockout
FGF10
Receptor Protein-Tyrosine Kinases
Cell Differentiation
Receptors, Fibroblast Growth Factor
Cell biology
DNA-Binding Proteins
Fibroblast Growth Factors
medicine.anatomical_structure
Endocrinology
Fibroblast growth factor receptor
Female
PAX9 Transcription Factor
Fibroblast Growth Factor 10
Cell Division
Gene Deletion
Signal Transduction
Transcription Factors
Subjects
Details
- ISSN :
- 15506606 and 00221767
- Volume :
- 167
- Database :
- OpenAIRE
- Journal :
- The Journal of Immunology
- Accession number :
- edsair.doi.dedup.....3f0b91d92ba266861976ad87c88e2866