Back to Search
Start Over
Replication of European Rheumatoid Arthritis Loci in a Pakistani Population
- Source :
- The Journal of Rheumatology. 40:401-407
- Publication Year :
- 2013
- Publisher :
- The Journal of Rheumatology, 2013.
-
Abstract
- Objective.Genetic studies have identified several rheumatoid arthritis (RA) susceptibility loci in European-derived populations. The same biological pathways may be involved in determining the RA risk in different population groups. We sought to replicate the association of 33 single-nucleotide polymorphisms (SNP) from 31 RA susceptibility loci confirmed among Europeans in a unique Pakistani population.Methods.We genotyped 33 SNP in a sample of 366 Pakistanis that comprised related and unrelated cases and controls. Genotyping was performed using TaqMan assays and the results were analyzed with family case-control software.Results.Twelve of the 33 SNP were replicated in this sample with significant p values ranging from 7.05E-06 to 3.72E-02, the most significant being the KIF5A-PIP4K2C/rs1678542 SNP.Conclusion.Our observations suggest that a number of RA susceptibility loci and related pathways are shared across different populations.
- Subjects :
- Adult
Male
Genotype
Immunology
Population
Biology
Polymorphism, Single Nucleotide
Linkage Disequilibrium
White People
Arthritis, Rheumatoid
Asian People
Gene Frequency
Rheumatology
medicine
TaqMan
Humans
Immunology and Allergy
SNP
Genetic Predisposition to Disease
Pakistan
education
Genotyping
Alleles
Genetics
education.field_of_study
Pakistani population
Middle Aged
medicine.disease
Haplotypes
Genetic Loci
Case-Control Studies
Rheumatoid arthritis
Susceptibility locus
Female
Subjects
Details
- ISSN :
- 14992752 and 0315162X
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- The Journal of Rheumatology
- Accession number :
- edsair.doi.dedup.....3f073c52d1be4752f2586f2e2161b97d