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Pharmacological effect of gelsemine on anxiety-like behavior in rat
- Source :
- Behavioural brain research. 253
- Publication Year :
- 2013
-
Abstract
- The chemical compound gelsemine is the major active principle of the yellow jasmine (Gelsemium) that is generally claimed as possessing anxiolytic properties based on empirical and indirect knowledge. Surprisingly, gelsemine effect on anxiety has until now received only little attention. Here, we used the well-validated method for anxiety assessment, the elevated plus-maze combined with video-tracking, to measure gelsemine action on rat anxiety-like behavior. Rats were intraperitoneally injected (500μl/daily/7days) with gelsemine (10(-6), 10(-10) or 10(-14)M) or control solution. Diazepam (DZP) was used as positive standard anxiolytic and additional controls were naive rats similarly manipulated except being injected. Gelsemine or diazepam treatment did not affect the number of closed arm entries and rears illustrating the rat general activity. In contrast, gelsemine (10(-6) to 10(-10)M) or DZP increased dose-dependently the number of entries and the percent of time spent in the open arms indicating that gelsemine is an anxiolytic. Consistently, we observed that gelsemine (10(-6) to 10(-10)M) or DZP also decreased dose-dependently the percent of protected stretched attend postures, an ethological index of anxiety-like state. Altogether, our results constitute a solid set of fundamental data directly demonstrating anxiolytic properties of gelsemine. The report also opens new perspectives for the development of safe and effective gelsemine- or Gelsemium-based strategies against pathological anxiety.
- Subjects :
- Male
Elevated plus maze
medicine.drug_class
Pharmacology
Anxiety
Motor Activity
Anxiolytic
Developmental psychology
Gelsemine
Rats, Sprague-Dawley
Behavioral Neuroscience
Alkaloids
medicine
General activity
Animals
Maze Learning
Diazepam
Anxiety like
biology
Behavior, Animal
Dose-Response Relationship, Drug
biology.organism_classification
Gelsemium
Rats
Anti-Anxiety Agents
Exploratory Behavior
medicine.symptom
Psychology
Injections, Intraperitoneal
medicine.drug
Subjects
Details
- ISSN :
- 18727549
- Volume :
- 253
- Database :
- OpenAIRE
- Journal :
- Behavioural brain research
- Accession number :
- edsair.doi.dedup.....3f0329faaa046d3946ded6aafe58a72d