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Carboxyzincation Employing Carbon Dioxide and Zinc Powder: Cobalt-Catalyzed Multicomponent Coupling Reactions with Alkynes
- Source :
- Journal of the American Chemical Society. 138:5547-5550
- Publication Year :
- 2016
- Publisher :
- American Chemical Society (ACS), 2016.
-
Abstract
- Cobalt-catalyzed carboxyzincation reactions employing carbon dioxide and zinc metal powder are developed. By using alkynes as substrates, regio- and stereodefined (Z)-β-zincated acrylates are provided. The corresponding alkenylzinc moiety can be converted to various substituents, affording multisubstituted acrylic acids. Furthermore, by adding electron-deficient alkene to the reaction system, the four-component coupling reactions of alkyne, alkene, CO2, and the Zn atom proceed via carboxyzincation.
- Subjects :
- chemistry.chemical_classification
010405 organic chemistry
Chemistry
Alkene
Alkyne
chemistry.chemical_element
General Chemistry
Zinc
010402 general chemistry
01 natural sciences
Biochemistry
Catalysis
Coupling reaction
0104 chemical sciences
chemistry.chemical_compound
Colloid and Surface Chemistry
Carbon dioxide
Moiety
Organic chemistry
Cobalt
Subjects
Details
- ISSN :
- 15205126 and 00027863
- Volume :
- 138
- Database :
- OpenAIRE
- Journal :
- Journal of the American Chemical Society
- Accession number :
- edsair.doi.dedup.....3f024dfccc333040ae07445385d649f3