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Biosynthesis, Characterization, and Bioactivities Evaluation of Silver and Gold Nanoparticles Mediated by the Roots of Chinese Herbal Angelica pubescens Maxim
- Source :
- Nanoscale Research Letters
- Publisher :
- Springer Nature
-
Abstract
- A facile synthesis and biological applications of silver (DH-AgNps) and gold nanoparticles (DH-AuNps) mediated by the aqueous extract of Angelicae Pubescentis Radix (Du Huo) are explored. Du Huo is a medicinal root belonging to Angelica pubescens Maxim which possesses anti-inflammatory, analgesic, and antioxidant properties. The absorption spectra of nanoparticles in varying root extract and metal ion concentration, pH, reaction temperatures, and time were recorded by ultraviolet–visible (UV-Vis) spectroscopy. The presence of DH-AgNps and DH-AuNps was confirmed from the surface plasmon resonance intensified at ~414 and ~540 nm, respectively. Field emission transmission electron micrograph (FE-TEM) analysis revealed the formation of quasi-spherical DH-AgNps and spherical icosahedral DH-AuNps. These novel DH-AgNps and DH-AuNps maintained an average crystallite size of 12.48 and 7.44 nm, respectively. The biosynthesized DH-AgNps and DH-AuNps exhibited antioxidant activity against 2,2-diphenyl-1-picrylhydrzyl (DPPH) radicals and the former exhibited antimicrobial activity against clinical pathogens including Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella enterica. The expected presence of flavonoids, sesquiterpenes, and phenols on the nanoparticle surface were conjectured to grant protection against aggregation and free radical scavenging activity. DH-AgNps and DH-AuNps were further investigated for their cytotoxic properties in RAW264.7 macrophages for their potential application as drug carriers to sites of inflammation. In conclusion, this green synthesis is favorable for the advancement of plant mediated nano-carriers in drug delivery systems, cancer diagnostic, and medical imaging. Graphical abstract Schematic diagram of biosynthesis of DH-AgNps and DH-AuNps and evaluation of their bioactivities.
- Subjects :
- Antioxidant
Stereochemistry
DPPH
medicine.medical_treatment
Cytotoxicity
02 engineering and technology
Antimicrobial activity
010402 general chemistry
01 natural sciences
chemistry.chemical_compound
Antioxidant activity
Materials Science(all)
medicine
Gold nanoparticles
General Materials Science
Phenols
Surface plasmon resonance
biology
Nano Express
021001 nanoscience & nanotechnology
biology.organism_classification
Antimicrobial
RAW264.7
Condensed Matter Physics
0104 chemical sciences
chemistry
Colloidal gold
Angelica pubescens Maxim
Silver nanoparticles
0210 nano-technology
Drug carrier
Angelica pubescens
Nuclear chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 19317573
- Volume :
- 12
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nanoscale Research Letters
- Accession number :
- edsair.doi.dedup.....3efffbb16d6232c82f661f6303bce8f0
- Full Text :
- https://doi.org/10.1186/s11671-017-1833-2