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Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010-2018
- Source :
- Möller, V, Östholm-Balkhed, Å, Berild, D, Fredriksson, M, Gottfredsson, M, Holmbom, M, Järvinen, A, Kristjansson, M, Rydell, U, Sönksen, U W, Kolmos, H J & Hanberger, H 2021, ' Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010–2018 ', Infectious Diseases, vol. 53, no. 8, pp. 607-618 . https://doi.org/10.1080/23744235.2021.1910338
- Publication Year :
- 2021
- Publisher :
- Linköpings universitet, Avdelningen för inflammation och infektion, 2021.
-
Abstract
- Background The Nordic countries have comparable nationwide antibiotic resistance surveillance systems and individual antibiotic stewardship programmes. The aim of this study was to assess antibiotic resistance among major pathogens in relation to practice guidelines for hospital antibiotic treatment and antibiotic use in Nordic countries 2010-2018. Methods Antibiotic resistance among invasive isolates from 2010-2018 and aggregated antibiotic use were obtained from the European Centre for Disease Prevention and Control. Hospital practice guidelines were obtained from national or regional guidelines. Results Antibiotic resistance levels among Escherichia coli and Klebsiella pneumoniae were similar in all Nordic countries in 2018 and low compared to the European mean. Guidelines for acute pyelonephritis varied; 2nd generation cephalosporin (Finland), 3rd generation cephalosporins (Sweden, Norway), ampicillin with an aminoglycoside or aminoglycoside monotherapy (Denmark, Iceland and Norway). Corresponding guidelines for sepsis of unknown origin were 2nd (Finland) or 3rd (Sweden, Norway, Iceland) generation cephalosporins, carbapenems, (Sweden) combinations of penicillin with an aminoglycoside (Norway, Denmark), or piperacillin-tazobactam (all Nordic countries). Methicillin-resistant Staphylococcus aureus rates were 0-2% and empirical treatment with anti-MRSA antibiotics was not recommended in any country. Rates of penicillin non-susceptibility among Streptococcus pneumoniae were low (Funding Agencies|Region Ostergotland; VINNOVA Swedens innovation agencyVinnova
- Subjects :
- 0301 basic medicine
Antibiotic resistance
Finland/epidemiology
Antibiotics
practice guidelines as topic
Iceland
Infektionsmedicin
medicine.disease_cause
THERAPY
DEFINITIONS
0302 clinical medicine
030212 general & internal medicine
Norway
Drug Resistance, Microbial
General Medicine
FINLAND
Norway/epidemiology
Hospitals
3. Good health
Anti-Bacterial Agents
INVASIVE STREPTOCOCCUS-PNEUMONIAE
Infectious Diseases
Nordic countries
Antibiotic Stewardship
population characteristics
Microbiology (medical)
Methicillin-Resistant Staphylococcus aureus
medicine.medical_specialty
BACTEREMIA
CLONALITY
Infectious Medicine
medicine.drug_class
030106 microbiology
antibiotic stewardship
Anti-Bacterial Agents/pharmacology
Sepsis
03 medical and health sciences
medicine
Humans
Intensive care medicine
Iceland/epidemiology
Sweden
ANTIMICROBIAL RESISTANCE
General Immunology and Microbiology
SEPSIS
business.industry
Septic shock
SEPTIC SHOCK
STEWARDSHIP
medicine.disease
Methicillin-resistant Staphylococcus aureus
Bacteremia
3121 General medicine, internal medicine and other clinical medicine
Stewardship
business
Subjects
Details
- Language :
- English
- ISSN :
- 23744235
- Database :
- OpenAIRE
- Journal :
- Möller, V, Östholm-Balkhed, Å, Berild, D, Fredriksson, M, Gottfredsson, M, Holmbom, M, Järvinen, A, Kristjansson, M, Rydell, U, Sönksen, U W, Kolmos, H J & Hanberger, H 2021, ' Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010–2018 ', Infectious Diseases, vol. 53, no. 8, pp. 607-618 . https://doi.org/10.1080/23744235.2021.1910338
- Accession number :
- edsair.doi.dedup.....3efdb3452d54bd03e96194514e160b66