Thyroid stimulating hormone levels and geriatric syndromes: secondary nested case–control study of the Mexican Health and Aging Study

Does geriatric syndrome have an association with subclinical hypothyroidism. This study showed a greater incidence of GS in subjects 50 years and older with sub-clinical hypothyroidism, when compared to those with normal thyroid function. Endocrine assessment should be taken in account in frail individuals as part of an integral evaluation for patients. To determine the incidence of geriatric syndromes (GS) in community dwelling older adults with subclinical hypothyroidism. This is an analysis from the Mexican Health and Aging Study, of a subsample of 2089 subjects with TSH determination. From this last subsample, we included 1628 individuals with TSH levels in the subclinical range (4.5–10 µU/ml). The multivariate analysis showed that when comparing data obtained from the 2012 wave with the 2015 wave results, there was a significant incidence of some GS such as falls (OR 1.79, CI 1.16–2.77, p = 0.0116), fatigue (OR 2.17, CI 1.40–3.38, p = 0.0348) and depression (OR 1.70, CI 1.06–2.71, p = 0.0246) among the subclinical hypothyroidism group. This study showed a greater incidence of GS in subjects 50 years and older with sub-clinical hypothyroidism, when compared to those with normal thyroid function.