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Circulation of clonal populations of fluoroquinolone-resistant CTX-M-15-producing Escherichia coli ST410 in humans and animals in Germany
- Source :
- International journal of antimicrobial agents. 47(6)
- Publication Year :
- 2015
-
Abstract
- Multidrug-resistant Escherichia coli encoding CTX-M-type extended-spectrum β-lactamases (ESBLs) are isolated in increasing numbers from humans, companion animals and livestock, raising concern regarding the exchange and spread of isolates in these populations. In this study, whole-genome sequencing of CTX-M-15-producing E. coli isolates recently sampled from humans, companion animals, livestock and farm environments was performed. In total, 26 different sequence types (STs) were detected, of which ST410 was the most frequent and was the only ST present in all populations studied. Five clades (designated A–E) were detected within the ST410 isolates. In particular, isolates of clade B were present in all four populations and had core genomes that differed by less than 70 single nucleotide polymorphisms (SNPs). Isolates of clades B and C were also clonally marked, exhibiting identical chromosomal insertions of blaCTX-M-15 at distinct loci. These data provide strong evidence for the clonal dissemination of specific clades of CTX-M-15-producing E. coli ST410 in human and animal populations.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Livestock
Genotype
030106 microbiology
Biology
medicine.disease_cause
Genome
beta-Lactamases
03 medical and health sciences
Antibiotic resistance
Dogs
Drug Resistance, Multiple, Bacterial
Germany
Genetic variation
medicine
Environmental Microbiology
Escherichia coli
Animals
Humans
Pharmacology (medical)
Clade
Escherichia coli Infections
Genetics
Molecular Epidemiology
Molecular epidemiology
Genetic Variation
General Medicine
Sequence Analysis, DNA
Anti-Bacterial Agents
Infectious Diseases
Multilocus sequence typing
Genome, Bacterial
Fluoroquinolones
Multilocus Sequence Typing
Subjects
Details
- ISSN :
- 18727913
- Volume :
- 47
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- International journal of antimicrobial agents
- Accession number :
- edsair.doi.dedup.....3ef5cbab03ca08e08cd4fcfd78719c90