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Molecular Magnetic Resonance Imaging of Lung Fibrogenesis with an Oxyamine-Based Probe
- Source :
- Angewandte Chemie (International ed. in English). 56(33)
- Publication Year :
- 2017
-
Abstract
- Fibrogenesis is the active production of extracellular matrix in response to tissue injury. In many chronic diseases persistent fibrogenesis results in the accumulation of scar tissue, which can lead to organ failure and death. However, no non-invasive technique exists to assess this key biological process. All tissue fibrogenesis results in the formation of allysine, which enables collagen cross-linking and leads to tissue stiffening and scar formation. We report herein a novel allysine-binding gadolinium chelate (GdOA), that can non-invasively detect and quantify the extent of fibrogenesis using magnetic resonance imaging (MRI). We demonstrate that GdOA signal enhancement correlates with the extent of the disease and is sensitive to a therapeutic response.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Gadolinium
Pulmonary Fibrosis
Molecular Conformation
chemistry.chemical_element
Lysyl oxidase
01 natural sciences
Catalysis
Article
Extracellular matrix
03 medical and health sciences
chemistry.chemical_compound
Bleomycin
Mice
0302 clinical medicine
Fibrosis
medicine
Animals
Amines
Chelating Agents
Gadolinium-Chelate
Lung
medicine.diagnostic_test
010405 organic chemistry
Magnetic resonance imaging
General Medicine
General Chemistry
medicine.disease
Magnetic Resonance Imaging
0104 chemical sciences
030104 developmental biology
medicine.anatomical_structure
chemistry
Molecular Probes
030211 gastroenterology & hepatology
Allysine
2-Aminoadipic Acid
Subjects
Details
- ISSN :
- 15213773
- Volume :
- 56
- Issue :
- 33
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie (International ed. in English)
- Accession number :
- edsair.doi.dedup.....3ef39b7360b2420505da04ccc4baf264