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An Atropo-enantioselective Synthesis of Benzo-Linked Axially Chiral Indoles via Hydrogen-Bond Catalysis
- Source :
- Organic letters. 21(13)
- Publication Year :
- 2019
-
Abstract
- A variety of axially chiral biaryldiols were synthesized in good yields with excellent atropo-enantioselectivities through construction of axially chiral indoles catalyzed by asymmetric hydrogen-bond donors. In addition, the new axially chiral compounds were proved to be efficient and practical catalysts for asymmetric catalysis. The strategy not only provides a novel method to synthesize axially chiral compounds but also extends the scope of chiral catalysts.
- Subjects :
- Quantitative Biology::Biomolecules
Hydrogen bond catalysis
010405 organic chemistry
Chemistry
High Energy Physics::Lattice
High Energy Physics::Phenomenology
Organic Chemistry
Enantioselective synthesis
010402 general chemistry
01 natural sciences
Biochemistry
Combinatorial chemistry
0104 chemical sciences
Catalysis
Condensed Matter::Materials Science
Physical and Theoretical Chemistry
Axial symmetry
Subjects
Details
- ISSN :
- 15237052
- Volume :
- 21
- Issue :
- 13
- Database :
- OpenAIRE
- Journal :
- Organic letters
- Accession number :
- edsair.doi.dedup.....3eed40122a299fd9be1db6c1b1e8b72e